XRCC3 and CXCL1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		XRCC3	CXCL1
Description		X-ray repair cross complementing 3	C-X-C motif chemokine ligand 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Killing Of Cells Of Another Organism Intracellular Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)	Anxiety disorder ( 25390645) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)
Interacting Genes		22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7	13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3
Entrez ID		7517	2919
HPRD ID		07201	01119
Ensembl ID		ENSG00000126215	ENSG00000163739
Uniprot IDs		O43542 Q53XC8	P09341
PDB IDs			1MGS 1MSG 1MSH 1ROD 8K4O 8XWA 8XWV
Enriched GO Terms of Interacting Partners?		Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Positive Regulation Of Cell Population Proliferation Chemotaxis Leukocyte Chemotaxis Neutrophil Chemotaxis Locomotion Neutrophil Migration Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Leukocyte Migration Interleukin-8 Receptor Activity C-C Chemokine Binding Cell Migration Interleukin-8 Binding Cell Motility Regulation Of Cell Population Proliferation Chemokine Activity Cytokine-mediated Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway C-X-C Chemokine Receptor Activity Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Inflammatory Response CXCR Chemokine Receptor Binding Dendritic Cell Chemotaxis Response To Stress Branching Involved In Mammary Gland Duct Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Intracellular Signal Transduction Immune Response Chemokine Receptor Activity C-C Chemokine Receptor Activity Dendritic Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Antimicrobial Humoral Response Defense Response Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Cellular Response To Lipid Negative Regulation Of Programmed Cell Death Cellular Response To Molecule Of Bacterial Origin Fibroblast Proliferation Cytokine Activity Regulation Of Cell Migration Regulation Of Cell Motility
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