RAD51D and RNF138

Number of citations of the paper that reports this interaction (PubMedID 27195665)
31

Data Source:
BioGRID (enzymatic study)

		RAD51D	RNF138
Description		RAD51 paralog D	ring finger protein 138
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus Chromosome Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity	DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Wnt Signaling Pathway Protein Ubiquitination Cellular Response To Leukemia Inhibitory Factor
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7	18 interacting genes: APP CFAP206 EFEMP2 H3C1 LNX2 NTAQ1 PCBP4 QKI RAD51D TAF9 TCF7L2 TP53 TRIM8 UBC UBE2D2 UBE2D4 UBE2K UBE2W
Entrez ID		5892	51444
HPRD ID		04261	11508
Ensembl ID		ENSG00000185379	ENSG00000134758
Uniprot IDs		O75771	A0A140VJT9 Q8WVD3
PDB IDs		2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Macromolecule Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleus Regulation Of MiRNA Metabolic Process Post-translational Protein Modification Protein K48-linked Ubiquitination PML Body Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Small Molecule Metabolic Process Molecular Function Activator Activity MRNA 3'-UTR Binding Protein Heterodimerization Activity Replication Fork Chromosome Organization Regulation Of Protein Localization To Nucleus Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Protein Modification Process Regulation Of RNA Splicing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Protein K11-linked Ubiquitination Protein-N-terminal Glutamine Amidohydrolase Activity A Axonemal Microtubule Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Epigenetic Regulation Of Gene Expression Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Endosome To Plasma Membrane Transport Vesicle
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