RAD51D and ZNF774

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAD51D	ZNF774
Description		RAD51 paralog D	zinc finger protein 774
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle	Regulation Of Transcription By RNA Polymerase II
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2	Generic Transcription Pathway
Drugs
Diseases
GWAS			Male-pattern baldness ( 28196072) Rheumatoid arthritis ( 22446963)
Interacting Genes		49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7	77 interacting genes: BACH2 BEGAIN BLK BOLA2 BOLA2B CABP2 CALCOCO2 CARD9 CATSPER1 CCDC102B CCDC136 CCDC6 CCHCR1 CDK18 CDKN2D CEP63 CIB3 COL8A1 CPNE7 DTX2 DVL3 EFEMP2 EMD FAM124B FSD2 GABARAPL2 GEM GFAP GLRX3 GOLGA1 GOLGA2 GTPBP3 GYS1 GZMM HOXA1 HOXB5 HSF2BP IL16 IPO8 KANK2 KIFC3 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP4-5 LDOC1 LONRF1 MAGOHB MID2 MLH1 MTUS2 MYO15B NDOR1 NEK6 NID2 PIBF1 PICK1 PRPF31 PSMB1 RABEP1 RAD51D RBM11 SCNM1 SH2D4A SMAD3 STK16 TRAF2 TSTD2 USP49 VWC2 YJU2B ZNF165 ZNF417 ZNF48 ZNF526 ZNF572 ZNF587
Entrez ID		5892	342132
HPRD ID		04261	17571
Ensembl ID		ENSG00000185379	ENSG00000196391
Uniprot IDs		O75771	Q6NX45
PDB IDs		2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process	Protein Binding Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex
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