XRCC3 and ZSWIM7

Number of citations of the paper that reports this interaction (PubMedID 21965664)
23

Data Source:
BioGRID (pull down)

		XRCC3	ZSWIM7
Description		X-ray repair cross complementing 3	zinc finger SWIM-type containing 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm	Nucleus Shu Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Stabilization
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)	Blood pressure (smoking interaction) ( 25189868)
Interacting Genes		22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7	3 interacting genes: RAD51D UQCRB XRCC3
Entrez ID		7517	125150
HPRD ID		07201	19095
Ensembl ID		ENSG00000126215	ENSG00000214941
Uniprot IDs		O43542 Q53XC8	Q19AV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process	Telomere Maintenance Via Recombination Mitotic Recombination Four-way Junction DNA Binding ATP-dependent DNA Damage Sensor Activity Replication Fork Interstrand Cross-link Repair Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Chromosome, Telomeric Region Rad51C-XRCC3 Complex Telomere Maintenance Via Telomere Trimming Double-strand Break Repair DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Strand Invasion Resolution Of Mitotic Recombination Intermediates Chromosome Organization Respiratory Chain Complex Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C T-circle Formation Telomeric Loop Disassembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint DNA Repair Positive Regulation Of Cell Cycle Checkpoint Oxidative Phosphorylation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Reciprocal Meiotic Recombination DNA Metabolic Process ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding DNA Damage Response Homologous Recombination Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Aerobic Electron Transport Chain Regulation Of Chromosome Separation Microtubule Organizing Center Respiratory Electron Transport Chain Aerobic Respiration Regulation Of Mitotic Metaphase/anaphase Transition ATP Binding Electron Transport Chain
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