XRCC3 and PSMC3IP

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		XRCC3	PSMC3IP
Description		X-ray repair cross complementing 3	PSMC3 interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm	Condensed Nuclear Chromosome Nucleus Nucleoplasm DNA Recombinase Auxiliary Factor Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Recombinase Activator Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming	Meiotic Joint Molecule Formation DNA Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange	Meiotic recombination
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)	Colorectal or endometrial cancer ( 26621817) White blood cell count ( 32888494)
Interacting Genes		22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7	20 interacting genes: AR AURKA BCAR3 BRMS1 CASP8 CHEK2 ERBB2 ESR1 ESR2 FGFR4 FZR1 NOTCH2 NR3C1 PIK3CA PSMC3 RB1CC1 RXRA TGFB1 THRB XRCC3
Entrez ID		7517	29893
HPRD ID		07201	16362
Ensembl ID		ENSG00000126215	ENSG00000131470
Uniprot IDs		O43542 Q53XC8	A0A158RUX1 K7ERB6 Q9P2W1
PDB IDs
Enriched GO Terms of Interacting Partners?		Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process	Nuclear Receptor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Positive Regulation Of Metabolic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cell Death Programmed Cell Death Steroid Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Response To Lipid Liver Development Intracellular Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of MiRNA Transcription Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Myeloid Leukocyte Differentiation Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Animal Organ Development Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Positive Regulation Of Protein Metabolic Process
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