RAD51D and ZSWIM7

Number of citations of the paper that reports this interaction (PubMedID 16710300)
53

Data Source:
HPRD (in vivo)

		RAD51D	ZSWIM7
Description		RAD51 paralog D	zinc finger SWIM-type containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus Shu Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Stabilization
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS			Blood pressure (smoking interaction) ( 25189868)
Interacting Genes		49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7	3 interacting genes: RAD51D UQCRB XRCC3
Entrez ID		5892	125150
HPRD ID		04261	19095
Ensembl ID		ENSG00000185379	ENSG00000214941
Uniprot IDs		O75771	Q19AV6
PDB IDs		2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process	Telomere Maintenance Via Recombination Mitotic Recombination Four-way Junction DNA Binding ATP-dependent DNA Damage Sensor Activity Replication Fork Interstrand Cross-link Repair Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Chromosome, Telomeric Region Rad51C-XRCC3 Complex Telomere Maintenance Via Telomere Trimming Double-strand Break Repair DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Strand Invasion Resolution Of Mitotic Recombination Intermediates Chromosome Organization Respiratory Chain Complex Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C T-circle Formation Telomeric Loop Disassembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint DNA Repair Positive Regulation Of Cell Cycle Checkpoint Oxidative Phosphorylation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Reciprocal Meiotic Recombination DNA Metabolic Process ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding DNA Damage Response Homologous Recombination Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Aerobic Electron Transport Chain Regulation Of Chromosome Separation Microtubule Organizing Center Respiratory Electron Transport Chain Aerobic Respiration Regulation Of Mitotic Metaphase/anaphase Transition ATP Binding Electron Transport Chain
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