DVL2 and ARR3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DVL2	ARR3
Gene Name		dishevelled segment polarity protein 2	arrestin 3, retinal (X-arrestin)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Synapse
	Molecular Function	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association	Opsin Binding Protein Binding Phosphoprotein Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Protein Phosphorylation Endocytosis Signal Transduction Visual Perception
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263	23 interactors: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 CSNK2A2 CYTH1 DVL2 FSHR GNMT MAP2K7 OPN1MW OPN4 PARK2 PLK4 PTAFR PTGDS RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496
Entrez ID		1856	407
HPRD ID		03690	02358
Ensembl ID		ENSG00000004975	ENSG00000120500
Uniprot IDs		I3L2N2 O14641	P36575
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0	1XEH 2A34
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta	Protein-chromophore Linkage Regulation Of Carbohydrate Metabolic Process Response To External Stimulus Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Phototransduction, Visible Light Detection Of Visible Light Phototransduction Detection Of Light Stimulus Regulation Of Glucose Metabolic Process Regulation Of MAPK Cascade Response To Light Stimulus Positive Regulation Of Organelle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Rhodopsin Mediated Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Response To Abiotic Stimulus Cellular Metabolic Process Regulation Of JNK Cascade Bone Resorption G-protein Coupled Receptor Signaling Pathway Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Signaling Mitotic Spindle Checkpoint Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Chromosome Segregation Regulation Of Kinase Activity Cell Communication Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Lysosomal Transport Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Red, Far-red Light Phototransduction Regulation Of Cell Cycle Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Cellular Process
Tagcloud ?		adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt	arr2 arrestins arrs distributed gpcr gpcrs grk grk2 grk5 grk6 grks innate macrophages mechanistically modify responsiveness surprisingly talk tlr2 tlr3 tlr4 tlrs toll transcriptionally translational ubiquitously uncover vital
Tagcloud (Difference) ?		adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt	arr2 arrestins arrs distributed gpcr gpcrs grk grk2 grk5 grk6 grks innate macrophages mechanistically modify responsiveness surprisingly talk tlr2 tlr3 tlr4 tlrs toll transcriptionally translational ubiquitously uncover vital
Tagcloud (Intersection) ?