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DVL2 and AXIN1
Number of citations of the paper that reports this interaction (PubMedID
10829020
)
0
Data Source:
HPRD
(in vivo)
DVL2
AXIN1
Description
dishevelled segment polarity protein 2
axin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aggresome
Lateral Plasma Membrane
Nuclear Body
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Neural Tube Closure
Heart Looping
Heart Morphogenesis
Outflow Tract Morphogenesis
Regulation Of DNA-templated Transcription
Segment Specification
Heart Development
Intracellular Protein Localization
Wnt Signaling Pathway
Convergent Extension Involved In Neural Plate Elongation
Regulation Of Actin Cytoskeleton Organization
Segmentation
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Convergent Extension Involved In Organogenesis
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Cochlea Morphogenesis
Positive Regulation Of Neuron Projection Arborization
Positive Regulation Of Signal Transduction By P53 Class Mediator
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
1,4-Dithiothreitol
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Metabolite levels (
31628463
)
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Interacting Genes
105 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
AQP9
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
CUL1
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RAP1B
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
WWP2
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
Entrez ID
1856
8312
HPRD ID
03690
04819
Ensembl ID
ENSG00000004975
ENSG00000103126
Uniprot IDs
O14641
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
8WM9
8WMA
8WWR
8YR7
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
Enriched GO Terms of Interacting Partners
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Protein Binding
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Wnt Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Cytosol
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Protein Modification Process
Nucleoplasm
Cytoplasm
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Protein Modification Process
Cellular Component Assembly
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Enzyme Binding
Cytoskeleton
Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Negative Regulation Of RNA Metabolic Process
Post-translational Protein Modification
Autophagy
Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
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Tagcloud (Intersection)
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