DVL2 and DPPA2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DVL2	DPPA2
Gene Name		dishevelled segment polarity protein 2	developmental pluripotency associated 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Nucleus Nucleoplasm
	Molecular Function	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association	Chromatin Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Regulation Of Histone Methylation Lung-associated Mesenchyme Development Positive Regulation Of Stem Cell Proliferation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS			Corneal astigmatism ( 23761726)
Protein-Protein Interactions		61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263	16 interactors: AP2M1 DPPA4 DVL2 DVL3 FXR2 MCM10 MOAP1 PBXIP1 PLOD3 SDCBP2 SETD5 SPOP U2AF2 VTA1 ZCCHC10 ZNF250
Entrez ID		1856	151871
HPRD ID		03690	13248
Ensembl ID		ENSG00000004975	ENSG00000163530
Uniprot IDs		I3L2N2 O14641	Q7Z7J5
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta	Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Cochlea Development Outflow Tract Morphogenesis Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Intracellular Transport Canonical Wnt Signaling Pathway Cellular Localization Inner Ear Morphogenesis Convergent Extension Involved In Neural Plate Elongation Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Embryonic Development Protein Insertion Into Mitochondrial Membrane Basement Membrane Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Ear Morphogenesis Positive Regulation Of Stress-activated MAPK Cascade Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Convergent Extension Involved In Organogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization Positive Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Establishment Of Localization In Cell Positive Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Regulation Of Organ Morphogenesis Regulation Of Stress-activated MAPK Cascade Inner Ear Development Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Mitochondrial Outer Membrane Permeabilization Positive Regulation Of MAP Kinase Activity Endothelial Cell Morphogenesis Tube Development Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Ear Development
Tagcloud ?		adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt	butyrate demethylation derivation efficiency enhances greatly insights ips karyotypes klf4 microarrays naturally nutritional permeable piggybac pluripotency pluripotent refractory remarkable reprogramming retroviral sickle somatic stimulation substitutes supplement transgene transposon vectors
Tagcloud (Difference) ?		adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt	butyrate demethylation derivation efficiency enhances greatly insights ips karyotypes klf4 microarrays naturally nutritional permeable piggybac pluripotency pluripotent refractory remarkable reprogramming retroviral sickle somatic stimulation substitutes supplement transgene transposon vectors
Tagcloud (Intersection) ?