CIB1 and PAX7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIB1	PAX7
Description		calcium and integrin binding 1	paired box 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Lamellipodium Axon Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Chromatin Nucleus
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process DNA Damage Response Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatogenesis Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Skeletal Muscle Tissue Development Anatomical Structure Morphogenesis Regulation Of Cell Fate Commitment Regulation Of Gene Expression Skeletal Muscle Satellite Cell Commitment Skeletal Muscle Satellite Cell Differentiation Spinal Cord Association Neuron Differentiation Dorsal/ventral Neural Tube Patterning Negative Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Embryonic Skeletal System Development Cartilage Development Muscle Tissue Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Myoblast Proliferation
Pathways			Specification of the neural plate border
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Alveolar rhabdomyosarcoma
GWAS			Body mass index ( 23669352) Cortical surface area (visual PC2) ( 32198502) Knee osteoarthritis ( 28916551) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Orofacial cleft x maternal periconceptional alcohol use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional smoking interaction (2df) ( 33937227) Orofacial clefts ( 22863734) Percentage gas trapping ( 26030696) Response to amphetamines ( 22952603) Urate levels in lean individuals ( 25811787)
Interacting Genes		38 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS MAP3K5 NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17	14 interacting genes: AIRIM CIB1 CSNK2A1 CT55 FHL1 HIRA HNF1B HOMER3 KRTAP19-7 MAGOHB NEDD4 NFIC NFIX TCAP
Entrez ID		10519	5081
HPRD ID		03800	01331
Ensembl ID		ENSG00000185043	ENSG00000009709
Uniprot IDs		A0A140VK09 Q99828	P23759
PDB IDs		1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Kinetochore Kinase Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Binding Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Translation In Response To Stress Positive Regulation Of RNA Metabolic Process Gamma-secretase Complex Protein Serine Kinase Activity Signal Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Notch Receptor Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Translation In Response To Endoplasmic Reticulum Stress Amyloid-beta Formation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Biosynthetic Process Dorsal/ventral Neural Tube Patterning Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Stress Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Immune System Process Regulation Of RNA Metabolic Process T Cell Activation Centrosome Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of RNA Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Maturation Of 5.8S RRNA	Transmembrane Transporter Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Targeting To Vacuole Nucleic Acid Metabolic Process Animal Organ Morphogenesis DNA-templated Transcription Formation Of Structure Involved In A Symbiotic Process Epithelial Tube Formation Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development HIR Complex Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Male Germ Cell Proliferation Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Growth Regulation Of Potassium Ion Transmembrane Transport Channel Inhibitor Activity Chromatin Hepatoblast Differentiation Regulation Of Pronephros Size Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Potassium Ion Transport Phosphothreonine Residue Binding Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Skeletal Muscle Myosin Thick Filament Assembly G Protein-coupled Glutamate Receptor Binding Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Exon-exon Junction Subcomplex Mago-y14 Zinc Ion Import Into Golgi Lumen Protein Localization To Vacuole
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