CIB1 and NCK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIB1	NCK2
Description		calcium and integrin binding 1	NCK adaptor protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Lamellipodium Axon Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane Postsynaptic Density Synapse
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Metal Ion Binding	Phosphotyrosine Residue Binding Protein Binding Cytoskeletal Anchor Activity Signaling Receptor Complex Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Scaffold Protein Binding
	Biological Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process DNA Damage Response Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatogenesis Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Immunological Synapse Formation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Response To Endoplasmic Reticulum Stress Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Dendritic Spine Development Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways			Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching RHOU GTPase cycle RHOV GTPase cycle
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS			Addiction ( 23533358) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Anti-chlamydia trachomatis IgG seropositivity ( 33204752) Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494) Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes		38 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS MAP3K5 NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17	168 interacting genes: ABI1 ABI2 ABI3 ANKRD55 ANKS1B ARHGAP32 ATN1 AXIN1 AXL BCAR1 BCL11A BTG1 C4orf17 CBARP CBLB CCDC120 CCDC33 CD3E CHN1 CHN2 CIB1 CIPC CLEC17A CPSF6 CPSF7 CUEDC1 DDR1 DEFB124 DISC1 DLGAP4 DNM1 DOCK1 DOK1 DRAP1 DTX3 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EFS EGFR EIF3H ERBB2 ERBB3 ERBB4 FAM124A FAM47A FAM53C FAM83A FASLG FBXL19 FCRL2 FGFR1 FOSB FXR2 FYB1 GAB1 GAREM1 GGN HNRNPK HOMEZ HOXA1 HOXC4 HOXD8 HSF2BP ILK INCA1 INTS2 IRS1 KCTD17 KHDRBS1 KIAA0408 KIAA1217 KIT KLHL24 KLHL35 KPRP LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MBD6 MEOX2 MET MIA3 MNT MYPOP NCKIPSD NELFA NET1 NFKBID NHSL2 NPAS2 NPHS1 NR5A1 NTRK2 NUTM2F ONECUT3 PAK1 PBX4 PDGFRB PHETA1 PIK3AP1 PKD1 PKN2 PRDM6 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMD10 PTK2 RASSF7 RBBP8NL RBM26 REEP4 REL SCML2 SCX SF1 SF3A2 SF3B4 SHD SKAP2 SMARCB1 SNW1 SORBS2 SOS1 SPATA2L SPATC1L SPRY2 SRMS SRPK1 SRPK2 SSH3 SYNGAP1 SYNPO TCF4 TCP10L TMEM121 TNR TRIM27 TRIM41 TRIP6 TXK UBC USP32 VARS2 VPS37B WAS WASF1 WASL WBP11 WIPF2 ZBTB12 ZBTB42 ZBTB7B ZC2HC1A ZC2HC1B ZNF341 ZNF526 ZNF688
Entrez ID		10519	8440
HPRD ID		03800	05378
Ensembl ID		ENSG00000185043	ENSG00000071051
Uniprot IDs		A0A140VK09 Q99828	A0A0S2Z4M6 E7ERP6 O43639
PDB IDs		1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0	1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Kinetochore Kinase Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Binding Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Translation In Response To Stress Positive Regulation Of RNA Metabolic Process Gamma-secretase Complex Protein Serine Kinase Activity Signal Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Notch Receptor Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Translation In Response To Endoplasmic Reticulum Stress Amyloid-beta Formation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Biosynthetic Process Dorsal/ventral Neural Tube Patterning Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Stress Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Immune System Process Regulation Of RNA Metabolic Process T Cell Activation Centrosome Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of RNA Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Maturation Of 5.8S RRNA	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cell Migration SH3 Domain Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Activity Regulation Of Cell Projection Organization Identical Protein Binding Signaling Adaptor Activity Regulation Of Neuron Projection Development Signal Transduction Tube Morphogenesis Protein Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anchoring Junction Lamellipodium SCAR Complex Regulation Of RNA Metabolic Process Response To Growth Factor Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Receptor Complex Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Protein Kinase Binding Ephrin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cell Junction Organization Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Cellular Component Organization
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