CIB1 and ONECUT3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIB1	ONECUT3
Description		calcium and integrin binding 1	one cut homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Lamellipodium Axon Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process DNA Damage Response Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatogenesis Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS
Interacting Genes		38 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS MAP3K5 NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17	4 interacting genes: CIB1 NCK2 SH3RF1 ZMYND12
Entrez ID		10519	390874
HPRD ID		03800	18891
Ensembl ID		ENSG00000185043	ENSG00000205922
Uniprot IDs		A0A140VK09 Q99828	O60422
PDB IDs		1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Kinetochore Kinase Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Binding Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Translation In Response To Stress Positive Regulation Of RNA Metabolic Process Gamma-secretase Complex Protein Serine Kinase Activity Signal Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Notch Receptor Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Translation In Response To Endoplasmic Reticulum Stress Amyloid-beta Formation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Biosynthetic Process Dorsal/ventral Neural Tube Patterning Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Stress Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Immune System Process Regulation Of RNA Metabolic Process T Cell Activation Centrosome Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of RNA Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Maturation Of 5.8S RRNA	Positive Regulation Of Protein Metabolic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Signal Transduction Signal Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cell Communication Regulation Of Leukocyte Proliferation Regulation Of T Cell Activation Positive Regulation Of Translation In Response To Stress Cell Motility Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Supramolecular Fiber Organization Regulation Of Mononuclear Cell Proliferation Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Germ Cell Proliferation Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Male Germ Cell Proliferation Cell Projection Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Lamellipodium Regulation Of Male Germ Cell Proliferation MAP-kinase Scaffold Activity Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cell Communication Immunological Synapse Formation Dendritic Spine Development Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Population Proliferation Positive Regulation Of Signaling Filopodium Tip Microtubule Cytoskeleton Organization Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of MAPK Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Hemopoiesis Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Adhesion
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