VRK1 and VHL

Number of citations: 62 (PubMedID 37008055)
Data Source: BioGRID (unspecified method)

		VRK1	VHL
Name		VRK serine/threonine kinase 1	von Hippel-Lindau tumor suppressor
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Cytosol Cajal Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nucleosomal DNA Binding Histone H3S10 Kinase Activity Histone Binding Histone H3T3 Kinase Activity Protein Serine Kinase Activity Histone H2AX Kinase Activity	Transcription Elongation Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Chromatin Remodeling Protein Phosphorylation DNA Damage Response Mitotic Nuclear Membrane Disassembly Signal Transduction Cajal Body Organization Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cell Division Golgi Disassembly Positive Regulation Of Protein Localization To Chromatin Regulation Of Neuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Cellular Response To Hypoxia Regulation Of Cellular Response To Hypoxia Negative Regulation Of TORC1 Signaling Amyloid Fibril Formation
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Diseases		Pontocerebellar hypoplasia	von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma
GWAS		Bone ultrasound measurement (velocity of sound) ( 28472463 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Cognitive function ( 24684796 ) Copper levels ( 26025379 ) Fractures (paediatric) ( 32742401 ) Metabolite levels ( 23823483 ) Neutrophil count ( 21507922 ) Night sleep phenotypes ( 27126917 ) Staphylococcus aureus infection ( 24847357 )	Bullous pemphigoid ( 34011352 ) Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		9 interacting genes: H2BC21 H3C14 HIF1A NBN OGT PLK3 SRPK2 TP53 VHL	172 interacting genes: ACTB AHI1 AKT1 ANKEF1 ANKRD11 APP ARHGEF7 AURKA BEX2 BEX4 BRCA1 BRD4 CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CCT5 CCT7 CD44 CDC34 CDK1 CDK5RAP3 CDKN2A CERKL CHEK2 CLU COL4A2 COMMD1 CPNE5 CSNK2A1 CUL2 CUL5 DGKI DIDO1 DNAJA3 DSTN DVL2 E2F1 EEF1A1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR ERI1 ETFA FBXO28 FBXO34 FKBP8 FLNA FLOT1 FN1 GHET1 GPANK1 GPS1 GTF3C2 GUK1 H1-2 H2BC13 H4C16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IFT88 IKBKB ITPKC JADE1 KIF2C KIF3A KLF4 KLHL10 LANCL1 MAP1B MAP1LC3B MAP1S MDFI MRPS9 MSL2 MT-CO2 NCL NISCH NR4A1 NR4A2 NR4A3 NSUN5 NSUN7 OTUD6B PAX2 PDCD5 PFKP PHB2 PIAS4 PIWIL4 PKP2 PLD1 PLD2 POLR2G PPP1R13L PPP5C PRDX1 PRKCI PRKG1 PRMT1 PRMT8 PSMC1 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RERE RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SAP30 SARNP SAT2 SELENOP SETDB1 SKP2 SLC2A1 SLC3A2 SMC5 SNRNP200 SON SP1 SPARC SPATA22 SPZ1 STAMBP SUV39H2 TBK1 TDRD7 TEX35 TPT1 TRIM28 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2I USP20 USP33 USP9X UXT VAPB VBP1 VRK1 WSB1 YY1AP1 ZBTB17 ZNF197 ZNF200 ZNF512B ZNF668 ZNF827
Entrez ID		7443	7428
HPRD ID		03701	01905
Ensembl ID		ENSG00000100749	ENSG00000134086
Uniprot IDs		A0A7P0T838 A0A7P0TB08 H0YJF7 Q99986	A0A024R2F2 A0A0S2Z4K1 A0A8Q3WL21 P40337
PDB IDs		2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VXU 6VZH 7M10 7TAN 8F8Y 8V42	1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC 7CJB 7JTO 7JTP 7KHH 7PI4 7Q2J 7S4E 7Z6L 7Z76 7Z77 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8EI3 8EWV 8FY0 8FY1 8FY2 8G1P 8G1Q 8P0F 8PC2 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8VL9 8VLB 8WDK 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9EQJ 9EQM 9IPW
GO Terms Enriched among Interactors		Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleoplasm Neuroblast Proliferation Chromatin Organization Regulation Of Carbohydrate Catabolic Process P53 Binding Response To Stress Regulation Of Purine Nucleotide Metabolic Process Chromatin Remodeling R-loop Processing Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Precursor Cell Proliferation Signal Transduction By P53 Class Mediator Regulation Of Thymocyte Apoptotic Process Protein Heterodimerization Activity Negative Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Autophagy Mitotic G1/S Transition Checkpoint Signaling Lactate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Hypoxia Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Regulation Of TOR Signaling Cellular Response To Oxygen Levels Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Intracellular Signal Transduction Replication Fork 14-3-3 Protein Binding Nucleus Negative Regulation Of Mitotic Cell Cycle Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Phase Transition Regulation Of T Cell Apoptotic Process Protein-containing Complex Assembly Regulation Of Neuroblast Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Chromosome Regulation Of Primary Metabolic Process	Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Cytosol Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Macromolecule Metabolic Process Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Stability Chromatin Remodeling Positive Regulation Of Biosynthetic Process NF-kappaB Binding Response To Stress Negative Regulation Of Apoptotic Process Intracellular Signal Transduction