VRK1 and PLK3

Number of citations of the paper that reports this interaction (PMID 19103756)
13

Data Source:
HPRD (in vivo, in vitro)

		VRK1	PLK3
Gene Name		vaccinia related kinase 1	polo-like kinase 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Spindle Cytosol	Nucleus Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Nucleosomal Histone Binding Histone Kinase Activity (H3-S10 Specific) Histone Kinase Activity (H3-T3 Specific)	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Endocytosis Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Regulation Of Cell Shape Wnt Signaling Pathway Histone H3-S10 Phosphorylation Protein Autophosphorylation Cell Division Histone H3-T3 Phosphorylation Golgi Disassembly	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Pathways		Mitotic Prophase Nuclear Envelope Breakdown Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Neutrophil count ( 21507922)
Protein-Protein Interactions		5 interactors: HIST2H2BE HIST2H3C PLK3 SRPK2 TP53	14 interactors: AURKA CDC25C CENPU CHEK2 CIB1 MAP2K1 MAPK1 POU2F1 SNCA SNCB SUMO1 TP53 TRIP13 VRK1
Entrez ID		7443	1263
HPRD ID		03701	04222
Ensembl ID		ENSG00000100749	ENSG00000173846
Uniprot IDs		Q99986	Q9H4B4
PDB IDs		2KTY 2KUL 2LAV 3OP5	4B6L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Response To Stress Mitotic G1/S Transition Checkpoint Positive Regulation Of Neuron Death Response To Osmotic Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Nuclear Speck Organization Cellular Response To Oxygen Levels Chromatin Assembly Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia Chromatin Assembly Or Disassembly Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle DNA Packaging Golgi Disassembly Endomitotic Cell Cycle Negative Regulation Of Helicase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Regulation Of Neuron Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process DNA Conformation Change Mitochondrial DNA Repair Positive Regulation Of Cell Cycle Organelle Organization Regulation Of Neuron Death Immune Response Response To Hypoxia Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Golgi Inheritance Glial Cell Apoptotic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Oxidative Stress-induced Premature Senescence ER Overload Response Regulation Of Apoptotic Process Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Regulation Of Cell Death DNA Methylation On Cytosine	Cell Cycle Mitotic Cell Cycle Organelle Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Protein Metabolic Process Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Stability Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Double-strand Break Repair Regulation Of Golgi Inheritance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Metabolic Process Cell Division Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Golgi Organization Golgi Inheritance Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Growth Factor Stimulus Female Meiosis I DNA Repair Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Metabolic Process Regulation Of Protein Phosphorylation Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Aging Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Replicative Senescence G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Histone-serine Phosphorylation
Tagcloud ?		affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia	3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b
Tagcloud (Difference) ?		affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia	3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b
Tagcloud (Intersection) ?