VRK1 and H2BC21

Number of citations of the paper that reports this interaction (PubMedID 28927264)
51

Data Source:
BioGRID (affinity chromatography technology, pull down)

		VRK1	H2BC21
Description		VRK serine/threonine kinase 1	H2B clustered histone 21
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Cytosol Cajal Body	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nucleosomal DNA Binding Histone H3S10 Kinase Activity Histone Binding Histone H3T3 Kinase Activity Protein Serine Kinase Activity Histone H2AX Kinase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Chromatin Remodeling Protein Phosphorylation DNA Damage Response Mitotic Nuclear Membrane Disassembly Signal Transduction Cajal Body Organization Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cell Division Golgi Disassembly Positive Regulation Of Protein Localization To Chromatin Regulation Of Neuron Migration	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Pontocerebellar hypoplasia
GWAS		Bone ultrasound measurement (velocity of sound) ( 28472463) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive function ( 24684796) Copper levels ( 26025379) Fractures (paediatric) ( 32742401) Metabolite levels ( 23823483) Neutrophil count ( 21507922) Night sleep phenotypes ( 27126917) Staphylococcus aureus infection ( 24847357)
Interacting Genes		9 interacting genes: H2BC21 H3C14 HIF1A NBN OGT PLK3 SRPK2 TP53 VHL	73 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NEIL3 NPM1 PARP10 PARP9 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMU1 SPANXN2 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1
Entrez ID		7443	8349
HPRD ID		03701	03494
Ensembl ID		ENSG00000100749	ENSG00000184678
Uniprot IDs		A0A7P0T838 A0A7P0TB08 H0YJF7 Q99986	Q16778
PDB IDs		2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VXU 6VZH 7M10 7TAN 8F8Y 8V42	4NFT 6A7U 6KBB 6M4D 6M4G 6M4H 7BXT 7EA8 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8H1T 8SPS 8SPU 8SYP 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8YJF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleoplasm Neuroblast Proliferation Chromatin Organization Regulation Of Carbohydrate Catabolic Process P53 Binding Response To Stress Regulation Of Purine Nucleotide Metabolic Process Chromatin Remodeling R-loop Processing Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neural Precursor Cell Proliferation Signal Transduction By P53 Class Mediator Regulation Of Thymocyte Apoptotic Process Protein Heterodimerization Activity Negative Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Autophagy Mitotic G1/S Transition Checkpoint Signaling Lactate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Hypoxia Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Regulation Of TOR Signaling Cellular Response To Oxygen Levels Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Intracellular Signal Transduction Replication Fork 14-3-3 Protein Binding Nucleus Negative Regulation Of Mitotic Cell Cycle Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Phase Transition Regulation Of T Cell Apoptotic Process Protein-containing Complex Assembly Regulation Of Neuroblast Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Chromosome Regulation Of Primary Metabolic Process	Chromatin Organization Chromatin Remodeling Histone Binding Nucleoplasm Nucleus Protein Modification Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Macromolecule Metabolic Process Transferase Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K18 Acetyltransferase Activity
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