VIP and MEP1A

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
BioGRID (enzymatic study)

		VIP	MEP1A
Description		vasoactive intestinal peptide	meprin A subunit alpha
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity
	Biological Process	Response To Yeast G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Positive Regulation Of Cell Population Proliferation Antibacterial Humoral Response Antifungal Humoral Response Regulation Of Protein Localization Innate Immune Response Positive Regulation Of Protein Catabolic Process Epinephrine Secretion MRNA Stabilization Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Prolactin Secretion Positive Regulation Of CAMP/PKA Signal Transduction	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600)
Interacting Genes		11 interacting genes: CTNNA3 MEOX2 MEP1A MGST1 MME PRICKLE1 SGTA UBQLN2 UBQLN4 VIPR1 VIPR2	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		7432	4224
HPRD ID		15950	02666
Ensembl ID		ENSG00000146469	ENSG00000112818
Uniprot IDs		P01282	B7ZL91 Q16819
PDB IDs		2RRH 2RRI 8E3Z	7UAB 7UAC 7UAE 7UAF 7UAI
Enriched GO Terms of Interacting Partners?		Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Peptide Hormone Processing Positive Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Catabolic Process G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Signaling Receptor Ligand Precursor Processing Limb Development Proteolysis Cellular Response To Lipid Hydroperoxide Neuropeptide Processing Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Creatinine Metabolic Process TRC Complex Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Metalloendopeptidase Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Response To Lipid Hydroperoxide Substance P Catabolic Process Negative Regulation Of Autophagosome Maturation Extracellular Matrix Constituent Secretion Tear Secretion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Exopeptidase Activity BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Embryonic Nail Plate Morphogenesis Somite Specification	Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen
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