VIP and VIPR2

Number of citations of the paper that reports this interaction (PubMedID 8146174)
29

Data Source:
HPRD (in vitro, in vivo)

		VIP	VIPR2
Description		vasoactive intestinal peptide	vasoactive intestinal peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection	Plasma Membrane Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Response To Yeast G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Positive Regulation Of Cell Population Proliferation Antibacterial Humoral Response Antifungal Humoral Response Regulation Of Protein Localization Innate Immune Response Positive Regulation Of Protein Catabolic Process Epinephrine Secretion MRNA Stabilization Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Prolactin Secretion Positive Regulation Of CAMP/PKA Signal Transduction	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600)	Academic attainment (English) ( 33594131) Corneal astigmatism ( 30306274) Diastolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Diastolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hearing loss in noise exposure ( 33242228) Myopia (pathological) ( 23406873) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sub-foveal choroidal thickness ( 29844195)
Interacting Genes		11 interacting genes: CTNNA3 MEOX2 MEP1A MGST1 MME PRICKLE1 SGTA UBQLN2 UBQLN4 VIPR1 VIPR2	6 interacting genes: ADCYAP1 APP DBNDD2 ERBIN RGS14 VIP
Entrez ID		7432	7434
HPRD ID		15950	03576
Ensembl ID		ENSG00000146469	ENSG00000106018
Uniprot IDs		P01282	P41587 X5D7Q6 X5DP12
PDB IDs		2RRH 2RRI 8E3Z	2X57 7VQX 7WBJ
Enriched GO Terms of Interacting Partners?		Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Peptide Hormone Processing Positive Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Catabolic Process G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Signaling Receptor Ligand Precursor Processing Limb Development Proteolysis Cellular Response To Lipid Hydroperoxide Neuropeptide Processing Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Creatinine Metabolic Process TRC Complex Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Metalloendopeptidase Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Response To Lipid Hydroperoxide Substance P Catabolic Process Negative Regulation Of Autophagosome Maturation Extracellular Matrix Constituent Secretion Tear Secretion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Exopeptidase Activity BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Embryonic Nail Plate Morphogenesis Somite Specification	Positive Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of CAMP/PKA Signal Transduction Regulation Of Chemokine Production Peptide Hormone Receptor Binding Antifungal Humoral Response Response To Yeast Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Neuropeptide Hormone Activity Regulation Of Protein Kinase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Kinase Activity Regulation Of Signaling Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Neuron Projection Visual Learning Defense Response To Fungus Response To Fungus Visual Behavior Antibacterial Humoral Response Regulation Of Protein Phosphorylation Signaling Receptor Binding Signal Transduction Peptide Hormone Secretion Positive Regulation Of Chemokine Production Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Pituitary Adenylate Cyclase Activating Polypeptide Activity Peptide Secretion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Epinephrine Secretion Negative Regulation Of Kinase Activity Zygote Asymmetric Cell Division Negative Regulation Of Macromolecule Metabolic Process Neuron Projection Development Regulation Of Biological Quality Defense Response To Gram-negative Bacterium Hormone Secretion
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