VIP and VIPR2

Number of citations of the paper that reports this interaction (PMID 10801840)
23

Data Source:
HPRD (in vivo, in vitro)

		VIP	VIPR2
Gene Name		vasoactive intestinal peptide	vasoactive intestinal peptide receptor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Neuronal Cell Body	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding	G-protein Coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation G-protein Coupled Receptor Signaling Pathway Body Fluid Secretion Learning Or Memory Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Vasodilation MRNA Stabilization Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Prolactin Secretion	Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events	Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events
Drugs
Diseases
GWAS			Myopia (pathological) ( 23406873)
Protein-Protein Interactions		8 interactors: MEOX2 MEP1A MME PRICKLE1 SGTA UBQLN4 VIPR1 VIPR2	4 interactors: ADCYAP1 APP ERBB2IP VIP
Entrez ID		7432	7434
HPRD ID		15950	03576
Ensembl ID		ENSG00000146469	ENSG00000106018
Uniprot IDs		P01282	P41587 Q6ZN22
PDB IDs		2RRH 2RRI	2X57
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Digestion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV-A Creatinine Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Somite Specification Response To UV-A Negative Regulation Of Cardiac Muscle Cell Differentiation Cellular Response To UV-B	Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transport Positive Regulation Of Vasodilation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Vasodilation Positive Regulation Of Lyase Activity Single-organism Behavior Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Regulation Of Potassium Ion Transport Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Behavior Positive Regulation Of Cyclic Nucleotide Metabolic Process Secretion Regulation Of CAMP Biosynthetic Process Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Growth Cell Surface Receptor Signaling Pathway Basal Protein Localization Synaptic Growth At Neuromuscular Junction Neurological System Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Protein Metabolic Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Neurogenesis Cognition Cellular Calcium Ion Homeostasis Prolactin Secretion Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Negative Regulation Of Cell Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Penile Erection Positive Regulation Of Growth Hormone Secretion Neuron Remodeling Negative Regulation Of Transport
Tagcloud ?		acral angiopathy bep bleomycin carboplatin ceb dysfunctions ejaculatory erectile etoposide ifosfamide libido neuropathy nonseminomatous nstgct orchidectomy orgasm paresthesia pct phenomenon polychemotherapy posttreatment pvb raynaud retroperitoneal rrrtm sent substituted vinblastine	7q36 7qter affymetrix arise asymptomatic boy condensin delay deletion deletions dysmorphism encompassing esyt2 father grandfather harbored heterozygosity inherited mcph1 microcephaly mother ncapg2 novo paternal prenatal psychomotor retardation snp wdr60
Tagcloud (Difference) ?		acral angiopathy bep bleomycin carboplatin ceb dysfunctions ejaculatory erectile etoposide ifosfamide libido neuropathy nonseminomatous nstgct orchidectomy orgasm paresthesia pct phenomenon polychemotherapy posttreatment pvb raynaud retroperitoneal rrrtm sent substituted vinblastine	7q36 7qter affymetrix arise asymptomatic boy condensin delay deletion deletions dysmorphism encompassing esyt2 father grandfather harbored heterozygosity inherited mcph1 microcephaly mother ncapg2 novo paternal prenatal psychomotor retardation snp wdr60
Tagcloud (Intersection) ?