VIP and MME

Number of citations of the paper that reports this interaction (PMID 9313778)
6

Data Source:
HPRD (in vitro)

		VIP	MME
Gene Name		vasoactive intestinal peptide	membrane metallo-endopeptidase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Integral Component Of Membrane Axon Dendrite Neuron Projection Terminus Synapse Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Exopeptidase Activity Zinc Ion Binding Peptide Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation G-protein Coupled Receptor Signaling Pathway Body Fluid Secretion Learning Or Memory Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Vasodilation MRNA Stabilization Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Prolactin Secretion	Kidney Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Sensory Perception Of Pain Cellular Protein Metabolic Process Creatinine Metabolic Process Beta-amyloid Metabolic Process Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Candoxatril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan
Diseases
GWAS
Protein-Protein Interactions		8 interactors: MEOX2 MEP1A MME PRICKLE1 SGTA UBQLN4 VIPR1 VIPR2	16 interactors: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 SHC1 VIP
Entrez ID		7432	4311
HPRD ID		15950	00392
Ensembl ID		ENSG00000146469	ENSG00000196549
Uniprot IDs		P01282	P08473
PDB IDs		2RRH 2RRI	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Digestion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV-A Creatinine Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Somite Specification Response To UV-A Negative Regulation Of Cardiac Muscle Cell Differentiation Cellular Response To UV-B	Positive Regulation Of Vasodilation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Vasodilation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Response To Stimulus Response To Hormone Positive Regulation Of Heart Contraction Cell Activation Positive Regulation Of Metabolic Process Regulation Of CAMP Metabolic Process Response To Peptide Hormone Artery Smooth Muscle Contraction Response To Peptide Regulation Of Kinase Activity Tonic Smooth Muscle Contraction Positive Regulation Of Protein Metabolic Process Response To Insulin Cellular Chemical Homeostasis Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Second-messenger-mediated Signaling Blood Circulation Response To External Stimulus Intracellular Signal Transduction Response To Stimulus Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Vasoconstriction Positive Regulation Of Cellular Metabolic Process Vascular Smooth Muscle Contraction Histamine Secretion Negative Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Homeostasis Regulation Of Heart Rate Cellular Metal Ion Homeostasis Response To Abiotic Stimulus Phosphate-containing Compound Metabolic Process Histamine Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Development
Tagcloud ?		acral angiopathy bep bleomycin carboplatin ceb dysfunctions ejaculatory erectile etoposide ifosfamide libido neuropathy nonseminomatous nstgct orchidectomy orgasm paresthesia pct phenomenon polychemotherapy posttreatment pvb raynaud retroperitoneal rrrtm sent substituted vinblastine	adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Difference) ?		acral angiopathy bep bleomycin carboplatin ceb dysfunctions ejaculatory erectile etoposide ifosfamide libido neuropathy nonseminomatous nstgct orchidectomy orgasm paresthesia pct phenomenon polychemotherapy posttreatment pvb raynaud retroperitoneal rrrtm sent substituted vinblastine	adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Intersection) ?