XRCC4 and AHNAK

Number of citations of the paper that reports this interaction (PMID 15177040)
3

Data Source:
HPRD (in vitro, in vivo)

		XRCC4	AHNAK
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 4	AHNAK nucleoprotein
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Centrosome Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Cell Junction DNA Ligase IV Complex Nonhomologous End Joining Complex	Nucleus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane T-tubule Vesicle Sarcolemma Costamere Cell-cell Contact Zone Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity	Protein Binding S100 Protein Binding Poly(A) RNA Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency	Regulation Of RNA Splicing Protein Oligomerization Regulation Of Voltage-gated Calcium Channel Activity
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs		S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Hypertension ( 21626137)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		19 interactors: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM	8 interactors: AKT1 CDKN2A EGFR KLHL40 NOL9 POT1 S100B XRCC4
Entrez ID		7518	79026
HPRD ID		15951	14684
Ensembl ID		ENSG00000152422	ENSG00000124942
Uniprot IDs		Q13426 Q7Z763	B4DTV0 Q09666 Q9BVU3
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03	4DRW 4FTG 4HRG
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Polynucleotide 3' Dephosphorylation Single Strand Break Repair Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Apoptotic Process Programmed Cell Death Cellular Response To Stress B Cell Activation Cell Death Death Pro-B Cell Differentiation Cell Activation Immunoglobulin Production Response To Radiation Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination DNA Recombination Lymphoid Progenitor Cell Differentiation Response To Stress DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Autophosphorylation Regulation Of Voltage-gated Calcium Channel Activity DNA Catabolic Process Response To Ionizing Radiation Isotype Switching Lymphocyte Activation T Cell Differentiation V(D)J Recombination Mitotic Cell Cycle Checkpoint Regulation Of Protein Autophosphorylation Cellular Response To Stimulus Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Central Nervous System Development Response To Stimulus Regulation Of Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Response To UV-A Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Glial Cell Differentiation Response To Epidermal Growth Factor Positive Regulation Of Vasoconstriction Regulation Of Apoptotic Process Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Gliogenesis Regulation Of Cell Death Mitotic Cell Cycle Phase Transition Regulation Of Nitric-oxide Synthase Activity Cell Cycle Phase Transition Astrocyte Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Transferase Activity Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of DNA Replication Cellular Response To Mechanical Stimulus Apoptotic Mitochondrial Changes Response To Abiotic Stimulus Regulation Of Oxidoreductase Activity Regulation Of Intracellular Transport Alkanesulfonate Metabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of DNA Strand Elongation Response To Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Catalytic Activity Regulation Of Fibroblast Proliferation Cellular Response To Hypoxia Positive Regulation Of Signal Transduction Cellular Response To Decreased Oxygen Levels In Utero Embryonic Development Glial Cell Development Immune Response Cellular Response To Oxygen Levels Positive Regulation Of Synaptic Transmission Reactive Oxygen Species Metabolic Process
Tagcloud ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3	100a6 a9 aldehyde caveolin cytoskeleton discover employing esi exactive fgr grades initiate introduce itraq meningeal meningiomas mgs opportunities originating phosphohistidine platforms proteomic proteomics quadrupole quite s100 tof transgelin vinculin
Tagcloud (Difference) ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3	100a6 a9 aldehyde caveolin cytoskeleton discover employing esi exactive fgr grades initiate introduce itraq meningeal meningiomas mgs opportunities originating phosphohistidine platforms proteomic proteomics quadrupole quite s100 tof transgelin vinculin
Tagcloud (Intersection) ?