XRCC4 and AHNAK

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		XRCC4	AHNAK
Description		X-ray repair cross complementing 4	AHNAK nucleoprotein
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Nucleus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane T-tubule Vesicle Sarcolemma Costamere Cell-cell Contact Zone Membrane Raft Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	DNA Binding Protein Binding Ligase Activity Enzyme Binding Identical Protein Binding FHA Domain Binding	RNA Binding Protein Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To X-ray Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein Localization To Site Of Double-strand Break	Regulation Of RNA Splicing Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Plasma Membrane Repair
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs		S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 28714976) Blond vs. brown/black hair color ( 30531825) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cutaneous melanoma or hair colour ( 32341527) Gamma glutamyl transferase levels ( 33339817 29403010) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1) ( 28166213) Monocyte percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum alkaline phosphatase levels ( 31666285) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM	13 interacting genes: AKT1 CDKN2A EGFR FNDC3B KLHL40 MEOX2 NOL9 POT1 S100B SUMO2 USP7 WEE2-AS1 XRCC4
Entrez ID		7518	79026
HPRD ID		15951	14684
Ensembl ID		ENSG00000152422	ENSG00000124942
Uniprot IDs		Q13426 Q7Z763	B4DTV0 Q09666 Q9BVU3
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO 7LSY 7LT3 7M3P 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB	4DRW 4FTG 4HRG
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex Somatic Recombination Of Immunoglobulin Gene Segments Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Site Of Double-strand Break Protein Localization To Chromosome Somatic Cell DNA Recombination Single Strand Break Repair Somatic Diversification Of Immunoglobulins DNA Recombination Polynucleotide 3'-phosphatase Activity V(D)J Recombination DNA Ligase IV Complex Protein Localization To Site Of Double-strand Break Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Cellular Response To Stress Organelle Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Double-strand Break Repair Double-strand Break Repair Via Alternative Nonhomologous End Joining Nucleus Double-strand Break Repair Via Classical Nonhomologous End Joining Damaged DNA Binding Lymphoid Progenitor Cell Differentiation B Cell Activation Double-stranded RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Repair Response To Stress Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Positive Regulation Of Chromosome Organization Sin3-type Complex PML Body Regulation Of DNA Metabolic Process DNA Endonuclease Activity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair-dependent Chromatin Remodeling	Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Response To UV-A Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator SUMO Transferase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Regulation Of DNA Metabolic Process Regulation Of Cellular Localization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Myelination Regulation Of Cellular Response To Stress Regulation Of TRNA Methylation Response To Epidermal Growth Factor Ligase Inhibitor Activity Protein Sumoylation Multivesicular Body, Internal Vesicle Lumen FHA Domain Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Catabolic Process Regulation Of Post-translational Protein Modification Nucleoplasm Positive Regulation Of Cell Cycle G1/S Phase Transition
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