XRCC4 and NBN

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (two hybrid, biochemical)

		XRCC4	NBN
Description		X-ray repair cross complementing 4	nibrin
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Golgi Apparatus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body BRCA1-C Complex Chromosomal Region
	Molecular Function	DNA Binding Protein Binding Ligase Activity Enzyme Binding Identical Protein Binding FHA Domain Binding	Damaged DNA Binding Protein Binding Histone Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding DNA-binding Transcription Factor Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To X-ray Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein Localization To Site Of Double-strand Break	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing In Utero Embryonic Development Blastocyst Growth DNA Repair Double-strand Break Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neuroblast Proliferation Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Telomere Maintenance In Response To DNA Damage Mitotic G2/M Transition Checkpoint Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Regulation Of Cell Cycle R-loop Processing Protein K63-linked Ubiquitination T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		S-(Dimethylarsenic)Cysteine
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM	35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NABP2 NAT2 NCL PRKDC RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5
Entrez ID		7518	4683
HPRD ID		15951	04050
Ensembl ID		ENSG00000152422	ENSG00000104320
Uniprot IDs		Q13426 Q7Z763	A0A0C4DG07 O60934
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO 7LSY 7LT3 7M3P 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB	5WQD 7SID 8BAH
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex Somatic Recombination Of Immunoglobulin Gene Segments Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Site Of Double-strand Break Protein Localization To Chromosome Somatic Cell DNA Recombination Single Strand Break Repair Somatic Diversification Of Immunoglobulins DNA Recombination Polynucleotide 3'-phosphatase Activity V(D)J Recombination DNA Ligase IV Complex Protein Localization To Site Of Double-strand Break Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Cellular Response To Stress Organelle Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Double-strand Break Repair Double-strand Break Repair Via Alternative Nonhomologous End Joining Nucleus Double-strand Break Repair Via Classical Nonhomologous End Joining Damaged DNA Binding Lymphoid Progenitor Cell Differentiation B Cell Activation Double-stranded RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Repair Response To Stress Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Positive Regulation Of Chromosome Organization Sin3-type Complex PML Body Regulation Of DNA Metabolic Process DNA Endonuclease Activity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair-dependent Chromatin Remodeling	DNA Damage Response DNA Metabolic Process DNA Repair Double-strand Break Repair Response To Ionizing Radiation Nucleoplasm Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Recombination Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Response To Radiation Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Recombinational Repair Regulation Of Double-strand Break Repair Telomere Maintenance Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Telomere Organization Chromosome Nucleobase-containing Compound Metabolic Process Chromatin Organization Double-strand Break Repair Via Homologous Recombination Response To Gamma Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Site Of Double-strand Break Cellular Response To Ionizing Radiation Positive Regulation Of DNA Repair Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Organization Involved In Meiotic Cell Cycle Chromatin Remodeling Cellular Response To Gamma Radiation Positive Regulation Of Double-strand Break Repair DNA Binding Regulation Of Primary Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?