SIRT6 and CCNDBP1

Number of citations of the paper that reports this interaction (PMID 17131381)
12

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SIRT6	CCNDBP1
Gene Name		sirtuin 6	cyclin D-type binding-protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Chromatin Binding NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding	Protein Binding
	Biological Process	Protein ADP-ribosylation Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deacetylation Histone H3-K9 Modification Histone H3 Deacetylation	Cell Cycle Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AKT1 CCNDBP1 CHD3 ELF5 FAF1 RELA SKP2 STUB1 UBE2D1 VIM	70 interactors: AMPD2 ARHGAP22 ATP4B C22orf23 C6orf226 CCDC108 CCDC146 CCND1 CDK18 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM64A FAM74A4 GLIDR GRAP2 GSTK1 ILF2 IMP3 MAP2K2 MOS MRPL15 MRPS9 NAIF1 NANOS2 NEURL3 NUDCD3 PAXIP1 PIAS2 PMP2 PSMB10 PTF1A RBP5 RPL28 RPL39L RPLP0 RPS28 SIRT6 SPG7 STK25 SYF2 TEAD4 THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS ZBTB24 ZGPAT ZNF124 ZNF136 ZNF169 ZNF20 ZNF230 ZNF334 ZNF394 ZNF439 ZNF490 ZNF555 ZNF564 ZNF581 ZNF627 ZNF670 ZNF697 ZNF707 ZNRF2P1 ZSCAN26
Entrez ID		51548	23582
HPRD ID		12093	06156
Ensembl ID		ENSG00000077463
Uniprot IDs		B4DDV3 Q8N6T7	O95273
PDB IDs		3K35 3PKI 3PKJ 3ZG6	3AY5
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Mammary Gland Epithelial Cell Differentiation Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Growth Factor Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Catabolic Process Cell Cycle Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Proteolysis Positive Regulation Of Proteolysis Cellular Macromolecule Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Execution Phase Of Apoptosis Glycogen Cell Differentiation Involved In Embryonic Placenta Development Acetaldehyde Metabolic Process Catabolic Process Positive Regulation Of Ligase Activity Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 4 Signaling Pathway Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Epithelium Development Negative Regulation Of Signal Transduction Cellular Response To Hypoxia Mammary Gland Epithelium Development Cellular Response To Decreased Oxygen Levels Response To Extracellular Stimulus	Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Metabolic Process Translational Termination Translational Elongation Cellular Protein Complex Disassembly Protein Complex Disassembly Regulation Of Cellular Process Translational Initiation MRNA Catabolic Process Cellular Process Negative Regulation Of Cell Cycle RNA Catabolic Process Translation Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Mitotic DNA Damage Checkpoint Cotranslational Protein Targeting To Membrane Protein Targeting To ER Viral Process Mitotic DNA Integrity Checkpoint Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Histone H3-K36 Methylation Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Protein Localization To Endoplasmic Reticulum Regulation Of Meiosis Cellular Protein Metabolic Process Myeloid Dendritic Cell Activation Involved In Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Tagcloud ?		accompanying bend cat catalase cse cystathionine cytoprotection dehydrogenase dependently deprivation deteriorated dismutase endothelial gaseous h2s lactate lyase na2s ogd propargylglycine protected protective reperfusion simulated sirtuin sod sulfide superoxide transmitter	astrocyte astrocytes c6 cerebral challenge cns conditioned cortex designed distribution dynamic elucidate injection interactor lipopolysaccharide lps media neuroinflammation neuronal p29 pc12 pre silencing sirna splicing strategy strongly syf2 upregulation
Tagcloud (Difference) ?		accompanying bend cat catalase cse cystathionine cytoprotection dehydrogenase dependently deprivation deteriorated dismutase endothelial gaseous h2s lactate lyase na2s ogd propargylglycine protected protective reperfusion simulated sirtuin sod sulfide superoxide transmitter	astrocyte astrocytes c6 cerebral challenge cns conditioned cortex designed distribution dynamic elucidate injection interactor lipopolysaccharide lps media neuroinflammation neuronal p29 pc12 pre silencing sirna splicing strategy strongly syf2 upregulation
Tagcloud (Intersection) ?