Wiki-Pi
About
Search
People
Updates
Search
SIRT6 and TDG
Number of citations of the paper that reports this interaction (PubMedID
23240041
)
62
Data Source:
BioGRID
(two hybrid)
SIRT6
TDG
Description
sirtuin 6
thymine DNA glycosylase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromosome
Pericentric Heterochromatin
Nucleolus
Endoplasmic Reticulum
Site Of Double-strand Break
Site Of DNA Damage
Chromosome, Subtelomeric Region
Nucleus
Nucleoplasm
Plasma Membrane
PML Body
Molecular Function
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Corepressor Activity
RNA Binding
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Acyltransferase Activity
Glycosyltransferase Activity
Nucleotidyltransferase Activity
Histone Deacetylase Activity, NAD-dependent
Enzyme Regulator Activity
Chromatin DNA Binding
Nucleosome Binding
Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism
NAD-dependent Protein Lysine Deacetylase Activity
Histone Deacetylase Regulator Activity
Protein Homodimerization Activity
Metal Ion Binding
Histone H3K9 Deacetylase Activity, NAD-dependent
NAD+ Binding
Histone H3K18 Deacetylase Activity, NAD-dependent
NAD+-protein-arginine ADP-ribosyltransferase Activity
DNA Damage Sensor Activity
Histone H3K56 Deacetylase Activity, NAD-dependent
NAD-dependent Protein Demyristoylase Activity
NAD-dependent Protein Depalmitoylase Activity
NAD+-protein-lysine ADP-ribosyltransferase Activity
TORC2 Complex Binding
NAD+-protein Mono-ADP-ribosyltransferase Activity
Magnesium Ion Binding
Mismatch Base Pair DNA N-glycosylase Activity
Nucleic Acid Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Transcription Coregulator Activity
Uracil DNA N-glycosylase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
Hydrolase Activity
DNA N-glycosylase Activity
Protein Domain Specific Binding
Mismatched DNA Binding
Sodium Ion Binding
Chloride Ion Binding
SUMO Binding
G/U Mismatch-specific Uracil-DNA Glycosylase Activity
DNA-binding Transcription Factor Binding
G/T Mismatch-specific Thymine-DNA Glycosylase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Gluconeogenesis
Glycolytic Process
Regulation Of Gluconeogenesis
DNA Repair
Regulation Of DNA Repair
Base-excision Repair
Double-strand Break Repair
Chromatin Organization
Chromatin Remodeling
Protein Deacetylation
Protein Import Into Nucleus
Inflammatory Response
DNA Damage Response
Ras Protein Signal Transduction
Negative Regulation Of Cell Population Proliferation
Determination Of Adult Lifespan
Response To UV
Transposable Element Silencing
Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of Lipid Metabolic Process
Pericentric Heterochromatin Formation
Subtelomeric Heterochromatin Formation
Protein Destabilization
Positive Regulation Of Insulin Secretion
Positive Regulation Of Telomere Maintenance
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Circadian Regulation Of Gene Expression
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Ketone Biosynthetic Process
Negative Regulation Of Protein Import Into Nucleus
Glucose Homeostasis
Regulation Of Circadian Rhythm
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Glycolytic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of D-glucose Import
Positive Regulation Of Protein Export From Nucleus
Positive Regulation Of Fibroblast Proliferation
Regulation Of Protein Secretion
Regulation Of Lipid Catabolic Process
Protein Delipidation
Cardiac Muscle Cell Differentiation
Protein Poly-ADP-ribosylation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Protein Localization To Chromatin
Positive Regulation Of Protein Localization To Chromatin
DNA Repair-dependent Chromatin Remodeling
Transcription Pausing By RNA Polymerase II
Positive Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Chondrocyte Proliferation
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Protein Localization To Site Of Double-strand Break
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Stem Cell Differentiation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Base-excision Repair
Base-excision Repair, AP Site Formation
Chromatin Organization
DNA Damage Response
Epigenetic Regulation Of Gene Expression
Depyrimidination
Regulation Of Embryonic Development
Chromosomal 5-methylcytosine DNA Demethylation, Oxidation Pathway
Pathways
Pre-NOTCH Transcription and Translation
Processing of DNA double-strand break ends
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS
Glucagon levels in response to oral glucose tolerance test (fasting) (
29093273
)
Metabolite levels (
23823483
)
Interacting Genes
18 interacting genes:
AKT1
CCNDBP1
CDKN1B
CHD3
DDB2
ELF5
FAF1
H3C1
HUS1
MUTYH
RAD1
SKP2
STUB1
TDG
TSPYL2
UBE2D1
UBE3A
VIM
38 interacting genes:
AR
CREBBP
CRK
DDX39B
DNMT3B
DTL
EP300
EPM2A
ESR1
HUS1
IKZF1
JUN
JUNB
MX1
NKX2-1
NR3C1
PCNA
PGR
PML
RAD1
RAD23B
RAD51
RAD9A
RXRA
SERBP1
SETX
SIRT6
SKIL
SMAD4
SNIP1
STAT3
SUMO1
SUMO2
SUMO3
THRA
UBE2I
VDR
XPC
Entrez ID
51548
6996
HPRD ID
12093
03251
Ensembl ID
ENSG00000077463
ENSG00000139372
Uniprot IDs
B4DDV3
M0QXA0
M0R1N9
Q8N6T7
B4DI29
B4E127
G8JL98
Q13569
PDB IDs
3K35
3PKI
3PKJ
3ZG6
5MF6
5MFP
5MFZ
5MGN
5X16
5Y2F
6HOY
6QCD
6QCE
6QCH
6QCJ
6XUY
6XV1
6XV6
6XVG
6ZU4
7CL0
7CL1
8AK5
8AK6
8AK7
8AK8
8AK9
8AKA
8AKB
8AKC
8AKD
8AKE
8AKF
8AKG
8BL0
8BL1
8CNM
8CNO
8F86
8G57
8I2B
8OF4
9G7H
1WYW
2D07
2RBA
3UFJ
3UO7
3UOB
4FNC
4JGC
4XEG
4Z3A
4Z47
4Z7B
4Z7Z
5CYS
5FF8
5HF7
5JXY
5T2W
6U15
6U16
6U17
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Protein Polyubiquitination
Regulation Of Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Ubiquitination
DNA Metabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
DNA Damage Response
DNA Repair
Checkpoint Clamp Complex
Positive Regulation Of Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Meiotic Cell Cycle Checkpoint Signaling
Positive Regulation Of Protein Modification Process
Negative Regulation Of TORC1 Signaling
Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Reproductive Process
Damaged DNA Binding
DNA N-glycosylase Activity
Protein Modification By Small Protein Conjugation
Protein Autoubiquitination
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Cul4A-RING E3 Ubiquitin Ligase Complex
Negative Regulation Of TOR Signaling
Regulation Of DNA Metabolic Process
Ubiquitin-protein Transferase Activity
Base-excision Repair, AP Site Formation
Regulation Of TORC1 Signaling
Post-translational Protein Modification
Mammary Gland Epithelial Cell Differentiation
Positive Regulation Of Protein Polyubiquitination
Positive Regulation Of Metabolic Process
Positive Regulation Of DNA Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of DNA Replication
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Modification
Regulation Of Protein Polyubiquitination
Negative Regulation Of Cell Cycle
Response To Stress
Nucleoplasm
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor Activity
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Chromatin
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Nucleic Acid Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Enzyme Binding
Regulation Of Macromolecule Metabolic Process
DNA Damage Response
Nuclear Receptor-mediated Signaling Pathway
Negative Regulation Of Metabolic Process
Transcription Regulator Complex
Damaged DNA Binding
Rhythmic Process
DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Reproductive Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Hormone-mediated Signaling Pathway
Macromolecule Metabolic Process
Nuclear Steroid Receptor Activity
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Intracellular Receptor Signaling Pathway
Transcription Coactivator Binding
Response To UV
Response To Radiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?