USP9X and TDRD3

Number of citations of the paper that reports this interaction (PubMedID 28101374)
53

Data Source:
BioGRID (pull down, pull down)

		USP9X	TDRD3
Description		ubiquitin specific peptidase 9 X-linked	tudor domain containing 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Exon-exon Junction Complex DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Histone H3 Reader Activity Histone H4 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation	DNA Topological Change Chromatin Organization Positive Regulation Of DNA-templated Transcription
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases
GWAS		Migraine ( 27322543)	Breast size ( 22747683) Menopause (age at onset) ( 22267201 26414677) Verbal declarative memory ( 25648963)
Interacting Genes		32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL	7 interacting genes: FUS H3-4 POLR2A TOP3A TOP3B UBC USP9X
Entrez ID		8239	81550
HPRD ID		02091	11625
Ensembl ID		ENSG00000124486	ENSG00000083544
Uniprot IDs		A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008	Q9H7E2
PDB IDs		5VBD 5WCH 7YXX 7YXY	1WJI 2LTO 3PMT 3PNW 3S6W 5GVD 5GVE 5YJ8 6V9T 8JTN 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration	DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity DNA Topoisomerase Activity DNA Topological Change DNA Conformation Change Amyloid Fibril Formation K11-linked Deubiquitinase Activity RNA Topoisomerase Activity DNA Binding DNA Repair DNA Topoisomerase III-beta-TDRD3 Complex Nucleus RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA Binding RecQ Family Helicase-topoisomerase III Complex Isomerase Activity Chromosome Segregation Spermatogonial Cell Division Regulation Of RNA Splicing Chromosome Microfibril Binding DNA Metabolic Process Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Macromolecule Metabolic Process 5'-3' RNA Polymerase Activity DNA Damage Response DNA Replication-dependent Chromatin Assembly Positive Regulation Of TORC2 Signaling DNA Recombination Resolution Of DNA Recombination Intermediates Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling Chromosome Separation DNA Alkylation Repair Nucleic Acid Metabolic Process Co-SMAD Binding Regulation Of TORC2 Signaling Prp19 Complex Protein Import Into Peroxisome Matrix Ubiquitin Protein Ligase Binding Protein Tag Activity RNA Polymerase II, Core Complex Molecular Sequestering Activity K63-linked Deubiquitinase Activity
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