USP9X and BCL9

Number of citations of the paper that reports this interaction (PubMedID 31073027)
71

Data Source:
BioGRID (pull down)

		USP9X	BCL9
Description		ubiquitin specific peptidase 9 X-linked	BCL9 transcription coactivator
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cis-Golgi Network Sarcoplasm Beta-catenin-TCF Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation	Transcription By RNA Polymerase II Myotube Differentiation Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Migraine ( 27322543)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Schizophrenia (negative symptoms) ( 23382809) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 25760438)
Interacting Genes		32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL	6 interacting genes: BCL2L13 CTNNB1 MAP1LC3A PYGO1 PYGO2 USP9X
Entrez ID		8239	607
HPRD ID		02091	04000
Ensembl ID		ENSG00000124486	ENSG00000116128
Uniprot IDs		A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008	O00512 Q1JQ81
PDB IDs		5VBD 5WCH 7YXX 7YXY	2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9 8Y0P
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration	Canonical Wnt Signaling Pathway Spermatid Nucleus Differentiation Beta-catenin-TCF Complex Kidney Development Germ Cell Development Wnt Signaling Pathway Mitophagy Developmental Growth Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Reproductive Process Neuron Projection Extension Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Developmental Cell Growth Organelle Organization K11-linked Deubiquitinase Activity Autophagy Of Mitochondrion Nucleus Organization Spermatid Development Histone Acetyltransferase Regulator Activity Oviduct Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Fungiform Papilla Formation Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Centriole-centriole Cohesion Embryonic Skeletal Limb Joint Morphogenesis Lung Induction Neuron Migration Catenin-TCF7L2 Complex Developmental Growth Involved In Morphogenesis Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Glial Cell-neuron Signaling
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