USP9X and NEAT1

Number of citations of the paper that reports this interaction (PubMedID 32140098)
39

Data Source:
BioGRID (unspecified method)

		USP9X	NEAT1
Description		ubiquitin specific peptidase 9 X-linked	nuclear paraspeckle assembly transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection	RISC Complex Paraspeckles
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	MiRNA Binding Chromatin-protein Adaptor Activity Molecular Condensate Scaffold Activity MiRNA Inhibitor Activity Via Base-pairing RISC Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation	LncRNA-mediated Post-transcriptional Gene Silencing Chromatin Organization Regulation Of MRNA Export From Nucleus Nuclear Body Organization MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Inflammatory Response Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of MiRNA Catabolic Process
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases
GWAS		Migraine ( 27322543)	Acne (severe) ( 24927181) Glaucoma (primary open-angle) ( 29891935) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL	12 interacting genes: CTSD EGR1 GAR1 HACD3 MPC2 NEDD4L PINK1 RIMBP2 TRAF6 TUBB4A TUBB4B USP9X
Entrez ID		8239	283131
HPRD ID		02091
Ensembl ID		ENSG00000124486	ENSG00000245532
Uniprot IDs		A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008
PDB IDs		5VBD 5WCH 7YXX 7YXY
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration	Receptor Metabolic Process Protein Kinase B Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Recycling Regulation Of Protein Localization Interleukin-1-mediated Signaling Pathway Positive Regulation Of Post-translational Protein Modification Mitochondrial Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Organelle Organization Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Regulation Of Biological Quality Regulation Of Post-translational Protein Modification Cellular Response To Interleukin-8 Protein Ubiquitination K11-linked Deubiquitinase Activity Canonical NF-kappaB Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Insulin Catabolic Process Aspartic-type Peptidase Activity Autophagosome Organization Cysteine-type Endopeptidase Activity Antigen Processing And Presentation Autophagosome Assembly Insulin Receptor Recycling Positive Regulation Of Protein Metabolic Process Hemi-methylated DNA-binding Enzyme Binding Positive Regulation Of Protein Modification Process Cellular Response To Mycophenolic Acid Circadian Temperature Homeostasis Glomerular Mesangial Cell Proliferation Cellular Response To Heparin Regulation Of Progesterone Biosynthetic Process Response To Ischemia BMP Signaling Pathway Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Protein Stability Structural Constituent Of Cytoskeleton Internode Region Of Axon Intercellular Bridge Negative Regulation Of Sodium Ion Import Across Plasma Membrane
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