VDAC2 and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		VDAC2	ECT2
Description		voltage dependent anion channel 2	epithelial cell transforming 2
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Sperm Midpiece	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex
	Molecular Function	Nucleotide Binding Voltage-gated Monoatomic Ion Channel Activity Protein Binding ATP Binding Oxysterol Binding Lipid Binding Voltage-gated Monoatomic Anion Channel Activity Porin Activity Cholesterol Binding Phospholipid Scramblase Activity Phosphatidylcholine Binding Ceramide Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Anion Transport Lipid Transport Binding Of Sperm To Zona Pellucida Plasma Membrane Phospholipid Scrambling Phospholipid Translocation Transmembrane Transport Mitochondrial Outer Membrane Permeabilization Monoatomic Anion Transmembrane Transport Mitochondrial Transmembrane Transport	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Mitochondrial calcium ion transport	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Aluminium monostearate PRLX 93936
Diseases
GWAS			Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		12 interacting genes: ADRB2 APP BAK1 CFTR CYCS DUX4 DUX4L9 ECT2 HK1 NEDD4 NEDD4L RPS3A	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		7417	1894
HPRD ID		01904	11860
Ensembl ID		ENSG00000165637	ENSG00000114346
Uniprot IDs		A0A024QZT0 B4DKM5 P45880	Q9H8V3
PDB IDs		9EIH 9EII 9EIJ	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Transport Regulation Of Sodium Ion Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Protein-folding Chaperone Binding Positive Regulation Of CAMP/PKA Signal Transduction Receptor Catabolic Process Neuronal Dense Core Vesicle Transmembrane Transporter Binding Negative Regulation Of Potassium Ion Transmembrane Transport Enzyme Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Endocytosis Ionotropic Glutamate Receptor Signaling Pathway Receptor-mediated Endocytosis Cell Junction Organization Response To Radiation Cellular Response To Radiation Negative Regulation Of Potassium Ion Transport Positive Regulation Of Macromolecule Metabolic Process Neuromuscular Junction Development Cytosol Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Chemical Homeostasis Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of CAMP/PKA Signal Transduction Import Into Cell Positive Regulation Of Cell Communication Glutamate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential	Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination
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