VDAC2 and HK1

Number of citations of the paper that reports this interaction (PMID 8420959)
27

Data Source:
HPRD (in vitro)

		VDAC2	HK1
Gene Name		voltage-dependent anion channel 2	hexokinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Nucleoid Pore Complex Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft Sperm Principal Piece
	Molecular Function	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Fructokinase Activity Mannokinase Activity
	Biological Process	Anion Transport Negative Regulation Of Protein Polymerization Regulation Of Anion Transport Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycolytic Process Hexose Transport Pathogenesis Glucose Transport Hexose Metabolic Process Small Molecule Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport
Pathways			Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs			Alpha-D-Glucose-6-Phosphate Beta-D-Glucose Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS			Glycated hemoglobin levels ( 20858683 19096518) Hematocrit ( 19862010) Hemoglobin ( 19862010) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		8 interactors: ADRB2 APP BAK1 CYCS ECT2 HK1 NEDD4L RPS3A	5 interactors: APP ENO2 SCMH1 VDAC1 VDAC2
Entrez ID		7417	3098
HPRD ID		01904	00809
Ensembl ID		ENSG00000165637	ENSG00000156515
Uniprot IDs		P45880	A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs			1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Transport Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Response To Reactive Oxygen Species Homeostatic Process Cellular Homeostasis Positive Regulation Of Catalytic Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Binding Positive Regulation Of Proteolysis Chemical Homeostasis Negative Regulation Of Blood Pressure Apoptotic Signaling Pathway Apoptotic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Regulation Of Sodium Ion Transport Response To Stress Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Cell Death Death Regulation Of Protein Phosphorylation Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Cellular Cation Homeostasis Response To Radiation Cellular Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Metal Ion Homeostasis Response To Inorganic Substance Regulation Of Catalytic Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Systemic Arterial Blood Pressure Regulation Of Multicellular Organism Growth Regulation Of Phosphorylation Zymogen Activation Positive Regulation Of Cellular Metabolic Process Tissue Remodeling Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis	Learning Regulation Of Anion Transport Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition
Tagcloud ?		adrenals carbohydrate cholesterol continues enter gonads hormonal hormones initiating interact interacts location mam mature mitochondria mitochondrial ovaries pregnenolone processed processing prolactin reproduction star steroid steroidogenesis steroidogenic terminus tom22 transports	cerebellar cerebellum cerebrum changing demonstration detail e14 exception gestational hexokinase hk3 immunoreactivity infiltration isoforms isozymes layers ontogeny organs p45 phosphorylate postnatally prominent purkinje share speculate spleen track vi
Tagcloud (Difference) ?		adrenals carbohydrate cholesterol continues enter gonads hormonal hormones initiating interact interacts location mam mature mitochondria mitochondrial ovaries pregnenolone processed processing prolactin reproduction star steroid steroidogenesis steroidogenic terminus tom22 transports	cerebellar cerebellum cerebrum changing demonstration detail e14 exception gestational hexokinase hk3 immunoreactivity infiltration isoforms isozymes layers ontogeny organs p45 phosphorylate postnatally prominent purkinje share speculate spleen track vi
Tagcloud (Intersection) ?