UBXN1 and UBQLN1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)

		UBXN1	UBQLN1
Gene Name		UBX domain protein 1	ubiquilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Dendrite Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Neuronal Cell Body	Proteasome Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Binding	Protein Binding Kinase Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HOMER2 PLA2G4A PLAA SMAD1 SMURF1 TGFBR1 TRIM39 UBE2I UBQLN1 VCP	151 interactors: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CARKD CCL7 CCNB1 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 COL10A1 COL1A2 COLGALT2 COMTD1 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM127A FAM127B FAM127C FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LITAF MANBAL MCM7 MIEF1 MIEF2 MLLT6 MTOR NBL1 NDE1 NGLY1 NME3 NPPA NPY NUPL1 P4HB PBXIP1 PIK3IP1 PLA2G16 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SPARC SRGN STMN3 TARDBP TFF1 TICAM1 TMCO6 TMEM31 TMEM37 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBQLN4 UBXN1 UBXN4 VCP XPO4 ZFAND2B ZG16 ZG16B ZMYM4 ZNF343
Entrez ID		51035	29979
HPRD ID		11266	05440
Ensembl ID		ENSG00000162191	ENSG00000135018
Uniprot IDs		Q04323	Q9UMX0
PDB IDs			2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Ossification Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Osteoblast Differentiation Signal Transduction By Phosphorylation Regulation Of Cartilage Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signaling Positive Regulation Of Cell Death Positive Regulation Of Ossification Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Protein Metabolic Process Pharyngeal System Development Regulation Of Osteoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Postreplication Repair Inflammatory Response Activin Receptor Signaling Pathway Response To Organic Cyclic Compound Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Polyubiquitination Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Pattern Specification Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Cell Cycle Process Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Response To Stress Response To Organic Substance Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Histamine Cellular Response To Organic Substance Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Platelet Degranulation Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of ERBB Signaling Pathway Response To Histamine Chloride Transmembrane Transport Response To Organic Cyclic Compound Positive Regulation Of Protein Catabolic Process Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Gamma-aminobutyric Acid Signaling Pathway Response To Hypoxia Cell Communication Chloride Transport Notch Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cellular Response To Oxygen Levels Regulation Of Cellular Process Defense Response Positive Regulation Of Cell Cycle Cellular Response To Ammonium Ion Notch Receptor Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		adaptor antiviral dengue disrupts exhibits innate interferes mavs nile oligomerization potently repressing rig rlr rlrs sendai sensed signalosome stomatitis stringently strongest tlr3 tlr4 traf3 traf6 underscore vesicular west	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Difference) ?		adaptor antiviral dengue disrupts exhibits innate interferes mavs nile oligomerization potently repressing rig rlr rlrs sendai sensed signalosome stomatitis stringently strongest tlr3 tlr4 traf3 traf6 underscore vesicular west	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Intersection) ?