UBXN1 and ENTREP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		UBXN1	ENTREP1
Description		UBX domain protein 1	endosomal transmembrane epsin interactor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex	Endosome Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding	Protein Binding Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Negative Adaptation Of Signaling Pathway Receptor Internalization CXCL12-activated CXCR4 Signaling Pathway
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 CEBPA ENTREP1 HMGB1 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2	11 interacting genes: BAG3 CALCOCO2 NEDD4 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2
Entrez ID		51035	9413
HPRD ID		11266	16255
Ensembl ID		ENSG00000162191	ENSG00000135063
Uniprot IDs		A0A087WTZ5 Q04323	Q15884 Q8WU02
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity SMAD Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process I-SMAD Binding Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Kinase Binding Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Primary Metabolic Process BRCA1-B Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Regulation Of Metabolic Process Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Regulation Of Osteoblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Cell Communication Inflammatory Response Regulation Of Signaling Catabolic Process Regulation Of Protein Metabolic Process Mitotic G2/M Transition Checkpoint Protein Metabolic Process BMP Receptor Activity BRCA1-A Complex	Catabolic Process Autophagy Regulation Of Macroautophagy Autophagosome Polyubiquitin Modification-dependent Protein Binding Regulation Of Autophagy Macroautophagy Cytosol Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cation Transmembrane Transport Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Potassium Channel Inhibitor Activity Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Macroautophagy Negative Regulation Of Monoatomic Ion Transport Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin Ligase Complex Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Cytoplasm Cellular Response To Unfolded Protein Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Cellular Response To Topologically Incorrect Protein Negative Regulation Of Potassium Ion Transport Positive Regulation Of Autophagy Proteasomal Protein Catabolic Process Aggresome Regulation Of Protein Export From Nucleus Intracellular Protein Transport Protein-macromolecule Adaptor Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Transport Intracellular Protein Localization Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Organelle Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport
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