MED21 and PCBD2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		MED21	PCBD2
Gene Name		mediator complex subunit 21	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mediator Complex	Cellular_component Nucleus Mitochondrion
	Molecular Function	Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
	Biological Process	Blastocyst Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 18391951)
Protein-Protein Interactions		25 interactors: BLOC1S6 BRCA1 BTF3 CDK8 CDK9 ESR1 ESR2 HNF4A HTT MAGEB4 MED29 PCBD2 POLR2A SKP1 SSC5D TARBP2 TCEB3 TFG THRA THRB TP53 TRIM27 VAV2 ZNF655 ZSCAN1	31 interactors: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3
Entrez ID		9412	84105
HPRD ID		09156	17824
Ensembl ID		ENSG00000152944
Uniprot IDs		F5H872 Q13503	Q9H0N5
PDB IDs			4C45
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Gene Expression Gene Expression Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Steroid Hormone Regulation Of Viral Process Positive Regulation Of Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Viral Process Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipid Female Courtship Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Secretion Response To Stimulus Rhythmic Process Cellular Response To Stimulus Mating	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Negative Regulation Of Gene Expression Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Cell Death Death Stem Cell Maintenance Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Histone Modification Negative Regulation Of Cell Differentiation Stem Cell Development Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation
Tagcloud ?		accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin
Tagcloud (Difference) ?		accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin
Tagcloud (Intersection) ?