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MED21 and PCBD2
Number of citations of the paper that reports this interaction (PubMedID
20211142
)
41
Data Source:
BioGRID
(two hybrid)
MED21
PCBD2
Description
mediator complex subunit 21
pterin-4 alpha-carbinolamine dehydratase 2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Mediator Complex
Core Mediator Complex
Mitochondrion
Molecular Function
Transcription Coregulator Activity
Transcription Coactivator Activity
DNA-directed RNA Polymerase Activity
Protein Binding
Ubiquitin Protein Ligase Activity
Protein Binding
4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
Lyase Activity
Biological Process
Blastocyst Development
Regulation Of Transcription By RNA Polymerase II
Protein Ubiquitination
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Somatic Stem Cell Population Maintenance
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Preinitiation Complex Assembly
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Tetrahydrobiopterin Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Pathways
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
RSV-host interactions
Drugs
Diseases
GWAS
Dimensional psychopathology (Social) (
29496196
)
Bulimia nervosa (
23568457
)
Colorectal cancer (
23263487
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Height (
18391951
28552196
)
Type 2 diabetes (
24509480
)
Interacting Genes
30 interacting genes:
BLOC1S6
BORCS6
BRCA1
BTF3
CDK8
CDK9
CEBPA
ELOA
ESR1
ESR2
HGS
HNF4A
HTT
MAGEA6
MAGEB4
MIEF1
PCBD2
POLR2A
SKP1
SSC5D
TARBP2
TFG
THRA
THRB
TP53
TRIM27
TRIM72
VAV2
ZNF655
ZSCAN1
41 interacting genes:
AATF
APP
ASCC2
BCAS2
BRF1
C1D
CDC5L
CENPK
CERS3
CHAF1A
FBXO7
GTF2E1
GUCD1
HES4
IRF2BP1
KCNIP3
KLC3
LGALS14
MAGEA11
MAGEA6
MED21
MED30
MED4
MED7
MET
MRFAP1
PBXIP1
PCBD1
PHF14
PML
RUNX1T1
SNW1
SPG21
SSX3
SSX5
STAT3
TAL2
TGIF2LY
USP2-AS1
XBP1
ZZZ3
Entrez ID
9412
84105
HPRD ID
09156
17824
Ensembl ID
ENSG00000152944
ENSG00000132570
Uniprot IDs
A0A024RAW0
Q13503
Q9H0N5
PDB IDs
7EMF
7ENA
7ENC
7ENJ
7LBM
7NVR
8GXQ
8GXS
8T9D
8TQW
8TRH
4C45
Enriched GO Terms of Interacting Partners
?
DNA-templated Transcription
Nuclear Receptor Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Zinc Ion Binding
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Transcription Coactivator Binding
Regulation Of Macromolecule Biosynthetic Process
Intracellular Receptor Signaling Pathway
Female Courtship Behavior
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
MRNA Transcription
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Cis-regulatory Region Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Thyroid Hormone Receptor Signaling Pathway
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Primary Metabolic Process
Nuclear Estrogen Receptor Activity
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
DNA Binding
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor-mediated Signaling Pathway
Thyroid Hormone Binding
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Thyroid Hormone Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Enzyme Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Elongation By RNA Polymerase II
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Transcription Preinitiation Complex Assembly
Transcription Coactivator Activity
Core Mediator Complex
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Mediator Complex
Negative Regulation Of RNA Metabolic Process
Protein-DNA Complex Assembly
RNA Polymerase II Preinitiation Complex Assembly
Nuclear Vitamin D Receptor Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Transcription Coregulator Activity
Somatic Stem Cell Population Maintenance
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of DNA-templated Transcription Initiation
Regulation Of Transcription Initiation By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription Initiation
U2-type Catalytic Step 2 Spliceosome
Positive Regulation Of RNA Metabolic Process
Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Interleukin-6 Production
Regulation Of Interleukin-1 Beta Production
Regulation Of DNA-templated Transcription Elongation
Negative Regulation Of Metabolic Process
Transcription Corepressor Activity
Ubiquitin Ligase Complex
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Interleukin-1 Production
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Stem Cell Population Maintenance
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