MED21 and CDK8

Number of citations of the paper that reports this interaction (PMID 9710619)
87

Data Source:
HPRD (in vivo)

		MED21	CDK8
Gene Name		mediator complex subunit 21	cyclin-dependent kinase 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mediator Complex	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Blastocyst Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: BLOC1S6 BRCA1 BTF3 CDK8 CDK9 ESR1 ESR2 HNF4A HTT MAGEB4 MED29 PCBD2 POLR2A SKP1 SSC5D TARBP2 TCEB3 TFG THRA THRB TP53 TRIM27 VAV2 ZNF655 ZSCAN1	29 interactors: BCL6 CCNC CCNH CDKN2B CTD CTDP1 ERCC3 ESR1 ESR2 HIST2H3C MAML1 MBP MED12 MED21 MED25 MED26 MED8 MED9 MYC NRIP1 POLR2A SGCG SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53
Entrez ID		9412	1024
HPRD ID		09156	04422
Ensembl ID		ENSG00000152944	ENSG00000132964
Uniprot IDs		F5H872 Q13503	P49336
PDB IDs			3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Gene Expression Gene Expression Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Steroid Hormone Regulation Of Viral Process Positive Regulation Of Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Viral Process Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipid Female Courtship Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Secretion Response To Stimulus Rhythmic Process Cellular Response To Stimulus Mating	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Organ Development
Tagcloud ?		accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin	absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast
Tagcloud (Difference) ?		accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin	absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast
Tagcloud (Intersection) ?		homolog