MED21 and ZNF655

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MED21	ZNF655
Description		mediator complex subunit 21	zinc finger protein 655
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Nucleus Nucleolus Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Blastocyst Development Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	Generic Transcription Pathway
Drugs
Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)	Serum metabolite levels ( 23093944)
Interacting Genes		30 interacting genes: BLOC1S6 BORCS6 BRCA1 BTF3 CDK8 CDK9 CEBPA ELOA ESR1 ESR2 HGS HNF4A HTT MAGEA6 MAGEB4 MIEF1 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 TRIM72 VAV2 ZNF655 ZSCAN1	156 interacting genes: ACSL6 ANKRD11 AP1M1 ASB6 ASMTL ATOSB ATPAF2 BARD1 BORCS6 BYSL C8orf34 C8orf74 CAPN7 CARD9 CBY2 CCDC116 CCDC179 CCDC57 CCDC74A CCHCR1 CCNH CDC37 CDK4 CDR2L CEP57L1 CPNE7 CRACR2A CWF19L2 DBF4B DEUP1 DPF2 DUSP4 EGLN3 EIF4EBP1 EMILIN1 EVL EXOSC5 FADS2 FAM81A FAM81B FAM90A1 FARS2 FBXL9P FHL2 FKBP6 GEM GFAP GSTP1 GUCD1 HAPLN2 HEXIM2 HOMER3 HOOK1 HOXB5 HPCAL1 HSD3B7 HTT HUNK IDI1 IMP3 INTS10 INTS13 IP6K3 ITGB5 JRK KIFC3 KRT40 KRT76 KRT85 KRT86 KRTAP4-12 KRTAP5-9 KRTAP9-8 LCE3C LCE4A LCE5A LGALS14 LMO2 LNX1 MACO1 MAD2L2 MAGEA11 MAGEA2B MBD3 MED21 MEMO1 METTL21A MIS18A MITD1 MPP3 MRFAP1 MRPL28 MTMR9 MTUS2 MXI1 NAA10 NDC80 NECAB2 NGB NOTUM NUDT21 NUDT22 NXT2 OIP5 OSTF1 OTUD4 P2RX7 PBX3 PCSK5 PFKFB1 POLR1C PRR35 RIN3 RINT1 RRM1 RUNX1T1 SH2D4A SIGLEC6 SLC12A4 SMARCD1 SMG9 SPANXN2 SPRED1 SPRY3 SRGAP2B SZT2 TCEANC TEKT4 TEX28 THAP6 TIMM10 TLK1 TNS2 TRAF2 TRAF5 TRAPPC2 TRAPPC2B TRIM37 TRIM41 TRIM72 TRIP13 TSPYL4 TXNDC9 USHBP1 VAV1 VPS26C VPS9D1 XPA YPEL5 ZBTB16 ZC2HC1C ZNF330 ZNF552 ZNF648 ZNF792 ZNF837
Entrez ID		9412	79027
HPRD ID		09156	11673
Ensembl ID		ENSG00000152944	ENSG00000197343
Uniprot IDs		A0A024RAW0 Q13503	Q8N720
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	8PK6
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Nuclear Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Transcription Coactivator Binding Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Female Courtship Behavior RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding MRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Nuclear Estrogen Receptor Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Thyroid Hormone Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process	Protein Binding Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition TRAF2-GSTP1 Complex Keratinization Intermediate Filament
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