CHMP3 and CHMP4A

Number of citations: 73 (PubMedID 35831314)
Data Source: BioGRID (biochemical, two hybrid)

		CHMP3	CHMP4A
Name		charged multivesicular body protein 3	charged multivesicular body protein 4A
Structure
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Early Endosome Late Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	Autophagosome Membrane Kinetochore ESCRT III Complex Nucleus Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Amphisome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylcholine Binding Identical Protein Binding Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity ATPase Binding
	Biological Process	Plasma Membrane Repair Autophagy Apoptotic Process Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Suppression Of Viral Release By Host Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Regulation Of Endosome Size Protein Polymerization Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Regulation Of Early Endosome To Late Endosome Transport	Plasma Membrane Repair Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Protein Transport Macroautophagy Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Nervous System Process Protein Polymerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Plasma Membrane Tubulation Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport
Pathways		Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
GWAS		Adult body size ( 32376654 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Nicotine dependence symptom count ( 25555482 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: GCH1
Interacting Genes		14 interacting genes: APP CHMP2A CHMP2B CHMP4A CHMP4B FBXO7 HSPA13 IGFBP7 RAB11A SMAD1 SMAD5 STAMBP TNPO3 VAV2	14 interacting genes: CC2D1A CDK13 CHMP3 CHMP4B CHMP4C CHMP5 CHMP6 NTAQ1 NUTF2 PDCD6IP STAMBP SYT17 TTC19 VPS4A
Entrez ID		51652	29082
HPRD ID		15650	16597
Ensembl ID		ENSG00000115561	ENSG00000254505
Uniprot IDs		Q9Y3E7	Q9BY43
PDB IDs		2GD5 2XZE 3FRT 3FRV 7ZCG 7ZCH	3C3O 5MK1
GO Terms Enriched among Interactors		Kinetochore Microtubule Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Multivesicular Body Mitotic Metaphase Chromosome Alignment Viral Budding From Plasma Membrane Lysosomal Membrane Organization Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Chromosome Localization Mitotic Cytokinetic Process Endosome Organization Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Membrane Assembly Nuclear Pore Nucleus Organization Endosome Vesicle Fusion Organelle Membrane Fusion Regulation Of Organelle Assembly Endosomal Transport Membrane Coat Osteoblast Fate Commitment Plasma Membrane Organization Lysosomal Transport Cytosol Autophagy Organelle Fusion	Viral Budding Via Host ESCRT Complex Midbody Abscission Viral Budding Mitotic Cytokinetic Process Multivesicular Body Assembly Viral Budding From Plasma Membrane Multivesicular Body Organization Endosome Organization Cytokinetic Process Mitotic Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Regulation Of Mitotic Spindle Assembly Metaphase Chromosome Alignment Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Regulation Of Spindle Assembly Multivesicular Body-lysosome Fusion Chromosome Localization Nuclear Pore Late Endosome To Vacuole Transport Lysosomal Membrane Organization Nucleus Organization Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Kinetochore Microtubule Membrane Assembly Viral Process Multivesicular Body Membrane Vesicle Organization Vesicle Budding From Membrane Midbody Vesicle Fusion Organelle Membrane Fusion Multivesicular Body Regulation Of Centrosome Duplication Plasma Membrane Organization Lysosomal Transport Autophagosome Membrane Organelle Fusion Regulation Of Centrosome Cycle