SHROOM3

Description		shroom family member 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex Anchoring Junction
	Molecular Function	Actin Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Actin Filament Organization Pattern Specification Process Regulation Of Cell Shape Cellular Pigment Accumulation Apical Protein Localization
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Cardiometabolic and hematological traits ( 27668658) Chronic kidney disease ( 20383146 31152163 26831199) Coronary artery disease ( 29212778) Craniofacial microsomia ( 26853712) Creatinine levels ( 20383145 31015462 29403010) Estimated glomerular filtration rate ( 31451708 31152163 31015462 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 23535967 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 24777453 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Liver enzyme levels (alanine transaminase) ( 33972514) Magnesium levels ( 26058915 20700443) Microalbuminuria ( 31511532) Myocardial infarction ( 33532862) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Pulse pressure ( 27841878) Red blood cell count ( 27863252 32888494) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		4 interacting genes: DYNLL1 PTEN UBC VASP
Entrez ID		57619
HPRD ID		07053
Ensembl ID		ENSG00000138771
Uniprot IDs		B3KY47 Q8TF72
PDB IDs		6FBB 6FCP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Vesicle Clustering Plasma Membrane Bounded Cell Projection Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Phosphorylation Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Cellular Component Size Locomotor Rhythm Phosphatidylinositol-3-phosphate Phosphatase Activity Enzyme Binding Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Meiotic Spindle Assembly Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Myelin Maintenance Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Parental Behavior Protein Tag Activity Profilin Binding Negative Regulation Of Nitric Oxide Biosynthetic Process Nitric-oxide Synthase Regulator Activity Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing
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