SHROOM3 and DYNLL1

Number of citations of the paper that reports this interaction (PubMedID 14760703)
0

Data Source:
HPRD (in vitro)

		SHROOM3	DYNLL1
Description		shroom family member 3	dynein light chain LC8-type 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex Anchoring Junction	Kinetochore Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium COP9 Signalosome Microtubule Cytoskeleton Membrane Secretory Granule Dynein Complex Site Of Double-strand Break Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm
	Molecular Function	Actin Binding Actin Filament Binding	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Deoxyribonuclease Inhibitor Activity Scaffold Protein Binding
	Biological Process	Cell Morphogenesis Actin Filament Organization Pattern Specification Process Regulation Of Cell Shape Cellular Pigment Accumulation Apical Protein Localization	Apoptotic Process DNA Damage Response Microtubule-based Process Spermatid Development Substantia Nigra Development Positive Regulation Of Intracellular Transport Intraciliary Retrograde Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Pathways			Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Cardiometabolic and hematological traits ( 27668658) Chronic kidney disease ( 20383146 31152163 26831199) Coronary artery disease ( 29212778) Craniofacial microsomia ( 26853712) Creatinine levels ( 20383145 31015462 29403010) Estimated glomerular filtration rate ( 31451708 31152163 31015462 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 23535967 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 24777453 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Liver enzyme levels (alanine transaminase) ( 33972514) Magnesium levels ( 26058915 20700443) Microalbuminuria ( 31511532) Myocardial infarction ( 33532862) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Pulse pressure ( 27841878) Red blood cell count ( 27863252 32888494) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		4 interacting genes: DYNLL1 PTEN UBC VASP	108 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BACH1 BCAS1 BCL2L11 BMF C14orf119 C19orf44 CA2 CACNB1 CCDC28A CIMAP1A CLIP2 COXFA4L2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 DYRK1A EEF1A1 ERG28 FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORC3 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 REDIC1 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710
Entrez ID		57619	8655
HPRD ID		07053	03334
Ensembl ID		ENSG00000138771	ENSG00000088986
Uniprot IDs		B3KY47 Q8TF72	P63167 Q6FGH9
PDB IDs		6FBB 6FCP	1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2 7D35 8PR0 8PR1 8PTK 8RGG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Vesicle Clustering Plasma Membrane Bounded Cell Projection Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Phosphorylation Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Cellular Component Size Locomotor Rhythm Phosphatidylinositol-3-phosphate Phosphatase Activity Enzyme Binding Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Meiotic Spindle Assembly Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Myelin Maintenance Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Parental Behavior Protein Tag Activity Profilin Binding Negative Regulation Of Nitric Oxide Biosynthetic Process Nitric-oxide Synthase Regulator Activity Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing	Cytoskeleton Microtubule Cytoplasm Postsynaptic Density Microtubule Binding Neurotrophin Receptor Activity Neurotrophin Binding Cytosol Pyruvate Metabolic Process Neuron Projection Morphogenesis Nucleotide Binding Cell Projection Morphogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Cytoskeleton Organization Actin Filament Identical Protein Binding ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Microtubule-based Process Apical Junction Complex ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Cellular Component Biogenesis Replication Fork CAMP-dependent Protein Kinase Inhibitor Activity Cytoskeleton-dependent Intracellular Transport Dendritic Spine Organelle Organization Axon Establishment Of Organelle Localization Axonogenesis Microtubule Associated Complex Carbohydrate Catabolic Process Peptidyl-cysteine S-nitrosylase Activity 6-phosphofructokinase Activity 6-phosphofructokinase Complex Beta-tubulin Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Microtubule Cytoskeleton Organization Substantia Nigra Development Negative Regulation Of Protein Import Into Nucleus Myelination In Peripheral Nervous System Regulation Of Transport Nucleoside Diphosphate Metabolic Process Regulation Of Transepithelial Transport Calyx Of Held Fructose-6-phosphate Binding
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