XPO6 and PFN1

Number of citations of the paper that reports this interaction (PMID 14592989)
52

Data Source:
HPRD (in vitro)

		XPO6	PFN1
Gene Name		exportin 6	profilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Ran GTPase Binding Protein Transporter Activity	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding
	Biological Process	Protein Export From Nucleus	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly
Pathways			Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ACTB DIAPH1 NUP62 PFN1 VASP	30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ
Entrez ID		23214	5216
HPRD ID		10525	01452
Ensembl ID		ENSG00000169180	ENSG00000108518
Uniprot IDs		B3KW08 D3DWF9 Q96QU8	P07737
PDB IDs			1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?		Organelle Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Actin Filament-based Process Neural Tube Closure Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Neural Tube Formation Embryonic Epithelial Tube Formation Epithelial Tube Formation Neuron Projection Development Nervous System Development Tube Formation Positive Regulation Of Protein Complex Assembly Morphogenesis Of Embryonic Epithelium Regulation Of Actin Filament Polymerization Neuron Development Platelet Activation Neural Tube Development Developmental Process Cell Junction Assembly Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Positive Regulation Of Ruffle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Localization To Microtubule Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Stimulus Regulation Of Cellular Component Size Positive Regulation Of Cell Migration Cellular Response To Histamine Regulation Of Protein Complex Assembly Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Histamine Epithelial Tube Morphogenesis Generation Of Neurons Axon Guidance Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process	Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion
Tagcloud ?			a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Difference) ?			a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Intersection) ?