FAT1 and MT-ND1

Number of citations: 0 (PubMedID 28129444)
Data Source: BioGRID (two hybrid)

		FAT1	MT-ND1
Name		FAT atypical cadherin 1	NADH dehydrogenase subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Perinuclear Region Of Cytoplasm Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Respiratory Chain Complex I
	Molecular Function	Calcium Ion Binding Protein Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Lens Development In Camera-type Eye Epithelial Cell Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Cell Migration Camera-type Eye Development Cell-cell Adhesion Mediated By Cadherin Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Camera-type Eye Morphogenesis Cell-cell Adhesion Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Response To Hypoxia Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Response To Xenobiotic Stimulus Mitochondrial Respiratory Chain Complex I Assembly Response To Hydroperoxide Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		None	Mitochondrial translation termination Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs		None	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate
Diseases		None	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS		Alzheimer disease and age of onset ( 26830138 ) Carotid plaque burden ( 28282560 ) Chronotype ( 26955885 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Macular thickness ( 30535121 ) Major depressive disorder ( 29317602 ) Medication use (calcium channel blockers) ( 31015401 ) Mild obesity-related type 2 diabetes ( 34737425 ) Morning vs. evening chronotype ( 26955885 ) Obesity ( 21552555 ) PR interval ( 30046033 32439900 ) Triglyceride levels in HIV infection ( 33109212 ) Urinary albumin-to-creatinine ratio ( 31630189 )	No GWAS studies recorded
Interacting Genes		12 interacting genes: CLK1 ENAH HOMER1 HOMER3 IGLL1 MT-ND1 NOXA1 SORBS2 TRAF4 TRIM14 UBC VASP	13 interacting genes: BARD1 BRCA1 DHDDS FAT1 LIG4 MEOX2 NDUFS7 PAXIP1 RPL13A RPL6 SIRPA TSC1 TST
Entrez ID		2195	4535
HPRD ID		02986	08365
Ensembl ID		ENSG00000083857	ENSG00000198888
Uniprot IDs		Q14517	P03886 U5Z754
PDB IDs		Not available	5XTC 5XTD
GO Terms Enriched among Interactors		G Protein-coupled Glutamate Receptor Binding Profilin Binding SH3 Domain Binding G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry Anchoring Junction WW Domain Binding Dendrite Lamellipodium Postsynapse Glutamate Receptor Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Synaptic Transmission, Glutamatergic Filopodium Signaling Adaptor Activity Protein Tetramerization	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Response To Ionizing Radiation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cell Cycle G2/M Phase Transition Large Ribosomal Subunit Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Cellular Response To Radiation Response To Radiation Condensed Chromosome Homologous Recombination DNA Repair Mitotic G2/M Transition Checkpoint Cellular Response To Stress Negative Regulation Of MRNA 3'-end Processing Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Establishment Of Integrated Proviral Latency Memory T Cell Differentiation Negative Regulation Of Formation Of Translation Preinitiation Complex Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Cytosolic Large Ribosomal Subunit Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Establishment Of Viral Latency Cyanate Catabolic Process 3-mercaptopyruvate Sulfurtransferase Activity Negative Regulation Of Cytoplasmic Translational Initiation Cellular Response To Type II Interferon Cellular Response To Interleukin-12 DNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Ubiquitin Ligase Complex DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoprotein Complex DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination