UQCRC2 and CACNA1A

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		UQCRC2	CACNA1A
Description		ubiquinol-cytochrome c reductase core protein 2	calcium voltage-gated channel subunit alpha1 A
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Proteolysis Aerobic Respiration Cellular Respiration	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		Respiratory electron transport Mitochondrial protein degradation Complex III assembly Complex III assembly	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2	Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS			Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		3 interacting genes: CACNA1A RTN4 UQCRC1	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		7385	773
HPRD ID		01876	03004
Ensembl ID		ENSG00000140740	ENSG00000141837
Uniprot IDs		P22695	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		5XTE 5XTH 5XTI	3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Cell Recognition Cell Projection Optic Nerve Morphogenesis Regulation Of Cell Junction Assembly Negative Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Synapse Assembly Negative Regulation Of Satellite Cell Differentiation Hindbrain Tangential Cell Migration Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Quinol-cytochrome-c Reductase Activity Cell Migration Involved In Vasculogenesis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Intracellular Sphingolipid Homeostasis Endoplasmic Reticulum Tubular Network Formation Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Endoplasmic Reticulum Tubular Network Membrane Organization Cerebral Cortex Radial Glia-guided Migration Positive Regulation Of Artery Morphogenesis Neuronal Cell Body Axon Guidance Receptor Activity Protein-containing Complex Binding Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Respiratory Chain Complex Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Artery Morphogenesis Positive Regulation Of Hepatocyte Proliferation Nuclear Pore Complex Assembly Cell Migration In Hindbrain High Voltage-gated Calcium Channel Activity Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Immunological Synapse Formation Cranial Nerve Morphogenesis Dendritic Spine Development Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Nervous System Development Ephrin Receptor Activity	Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome
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