UQCRC2 and RTN4

Number of citations of the paper that reports this interaction (PMID 12067236)
13

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		UQCRC2	RTN4
Gene Name		ubiquinol-cytochrome c reductase core protein II	reticulon 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Extracellular Vesicular Exosome	Intracellular Nuclear Envelope Endoplasmic Reticulum Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Protein Complex Binding Metal Ion Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Oxidative Phosphorylation Proteolysis Aerobic Respiration Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process	Angiogenesis Apoptotic Process Axonal Fasciculation Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Cardiac Epithelial To Mesenchymal Transition Endoplasmic Reticulum Tubular Network Organization Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Obesity (extreme) ( 19553259)
Protein-Protein Interactions		3 interactors: CACNA1A RTN4 UQCRC1	34 interactors: ARL6IP1 BAIAP2 BCL2 BCL2L1 CLN8 CNTNAP1 COL4A3BP CRMP1 FXR2 HLA-DPB1 LAMA4 LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		7385	57142
HPRD ID		01876	07259
Ensembl ID		ENSG00000140740	ENSG00000115310
Uniprot IDs		P22695	Q9NQC3
PDB IDs			2G31 2JV5
Enriched GO Terms of Interacting Partners?		Cerebellar Molecular Layer Development Regulation Of Axonogenesis Vestibular Nucleus Development Regulation Of Branching Morphogenesis Of A Nerve Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Energy Derivation By Oxidation Of Organic Compounds Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Regulation Of Neuron Projection Development Endoplasmic Reticulum Tubular Network Organization Generation Of Precursor Metabolites And Energy Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Negative Regulation Of Hormone Biosynthetic Process Pons Development Regulation Of Neuron Differentiation Cerebellar Purkinje Cell Differentiation Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Neurogenesis Reflex Cell Morphogenesis Involved In Differentiation Behavioral Response To Pain Axonal Fasciculation Neuromuscular Synaptic Transmission Negative Regulation Of Axon Extension Brain Development Cardiac Epithelial To Mesenchymal Transition Regulation Of Hormone Biosynthetic Process Head Development Cerebellar Cortex Formation Neuron Projection Development Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Regulation Of Cell Development Calcium Ion Import Regulation Of Hormone Metabolic Process Cerebellar Purkinje Cell Layer Development Membrane Depolarization During Action Potential Cation Transmembrane Transport Neuron Recognition Neuron Development Central Nervous System Development	Transport Establishment Of Localization In Cell Membrane Organization Cell Part Morphogenesis Intracellular Transport Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Mitochondrial Membrane Organization Regulation Of Telomere Maintenance Via Telomerase Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Anoikis Regulation Of Telomerase Activity Neuromuscular Process Controlling Posture Regulation Of Anoikis Regulation Of Telomere Maintenance Immune Response-regulating Signaling Pathway RNA-dependent DNA Replication Regulation Of Autophagy Mitochondrion Morphogenesis Cell Morphogenesis Negative Regulation Of DNA Biosynthetic Process Vesicle-mediated Transport Immune Response-activating Cell Surface Receptor Signaling Pathway System Development Neuron Differentiation Nervous System Development Axonogenesis Release Of Cytochrome C From Mitochondria Regulation Of Cellular Component Organization Cell Projection Morphogenesis Telomere Maintenance Via Telomere Lengthening Antigen Receptor-mediated Signaling Pathway Generation Of Neurons Anatomical Structure Development Aging Axon Development Developmental Process Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Response To Alkaloid Regulation Of Mitochondrial Membrane Permeability Cell Morphogenesis Involved In Neuron Differentiation Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Membrane Permeability Neurogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 usp27x	advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Difference) ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 usp27x	advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Intersection) ?