UQCRC2 and UQCRC1

Number of citations: 0 (PubMedID 11073949)
Data Source: HPRD (in vitro)

		UQCRC2	UQCRC1
Name		ubiquinol-cytochrome c reductase core protein 2	ubiquinol-cytochrome c reductase core protein 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Protein Binding Quinol-cytochrome-c Reductase Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Proteolysis Aerobic Respiration Cellular Respiration	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Response To Activity Response To Alkaloid Cellular Respiration Proton Transmembrane Transport
Pathways		Respiratory electron transport Mitochondrial protein degradation Complex III assembly Complex III assembly	Respiratory electron transport Complex III assembly Complex III assembly
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Myxothiazol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
GWAS		No GWAS studies recorded	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Metabolite levels ( 23823483 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: EPHB1	1 novel interactors: GPX1
Interacting Genes		3 interacting genes: CACNA1A RTN4 UQCRC1	11 interacting genes: BDKRB1 CYCS DSCAM ERCC6 HNRNPD KRAS NLGN3 OGT RTN4 TRIM63 UQCRC2
Entrez ID		7385	7384
HPRD ID		01876	01875
Ensembl ID		ENSG00000140740	ENSG00000010256
Uniprot IDs		P22695	P31930
PDB IDs		5XTE 5XTH 5XTI	5XTE 5XTH 5XTI
GO Terms Enriched among Interactors		Modulation Of Chemical Synaptic Transmission Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Cell Recognition Cell Projection Optic Nerve Morphogenesis Regulation Of Cell Junction Assembly Negative Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Synapse Assembly Negative Regulation Of Satellite Cell Differentiation Hindbrain Tangential Cell Migration Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Quinol-cytochrome-c Reductase Activity Cell Migration Involved In Vasculogenesis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Intracellular Sphingolipid Homeostasis Endoplasmic Reticulum Tubular Network Formation Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Endoplasmic Reticulum Tubular Network Membrane Organization Cerebral Cortex Radial Glia-guided Migration Positive Regulation Of Artery Morphogenesis Neuronal Cell Body Axon Guidance Receptor Activity Protein-containing Complex Binding Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Respiratory Chain Complex Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Artery Morphogenesis Positive Regulation Of Hepatocyte Proliferation Nuclear Pore Complex Assembly Cell Migration In Hindbrain High Voltage-gated Calcium Channel Activity Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Immunological Synapse Formation Cranial Nerve Morphogenesis Dendritic Spine Development Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Nervous System Development Ephrin Receptor Activity	Regulation Of Rac Protein Signal Transduction Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Myoblast Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rac Protein Signal Transduction Response To Lipid Regulation Of Nervous System Development Regulation Of Synapse Assembly Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Phosphorus Metabolic Process Social Behavior Neuron Recognition Protein Tyrosine Kinase Binding Synapse Response To Gamma Radiation Intrinsic Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Response To Hormone Response To Electrical Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cell Junction Assembly Regulation Of Glycolytic Process Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Nervous System Development Cellular Response To Glucose Stimulus Positive Regulation Of Gene Expression Regulation Of Carbohydrate Catabolic Process Bradykinin Receptor Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Axon Extension Cellular Developmental Process Positive Regulation Of Developmental Process Apoptotic Signaling Pathway Response To Light Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Carbohydrate Stimulus Striated Muscle Cell Differentiation Circadian Regulation Of Translation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction