UQCRC2 and UQCRC1

Number of citations of the paper that reports this interaction (PMID 11073949)
13

Data Source:
HPRD (in vitro)

		UQCRC2	UQCRC1
Gene Name		ubiquinol-cytochrome c reductase core protein II	ubiquinol-cytochrome c reductase core protein I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Mitochondrial Respiratory Chain Complex III
	Molecular Function	Metalloendopeptidase Activity Protein Binding Protein Complex Binding Metal Ion Binding	Ubiquinol-cytochrome-c Reductase Activity Protein Complex Binding Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Proteolysis Aerobic Respiration Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Response To Activity Respiratory Electron Transport Chain Response To Alkaloid Cellular Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Hydrogen Ion Transmembrane Transport
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Myxothiazol 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE FAMOXADONE METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE UBIQUINONE-2
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CACNA1A RTN4 UQCRC1	5 interactors: CYCS HNRNPD RTN4 TRIM63 UQCRC2
Entrez ID		7385	7384
HPRD ID		01876	01875
Ensembl ID		ENSG00000140740	ENSG00000010256
Uniprot IDs		P22695	P31930
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebellar Molecular Layer Development Regulation Of Axonogenesis Vestibular Nucleus Development Regulation Of Branching Morphogenesis Of A Nerve Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Energy Derivation By Oxidation Of Organic Compounds Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Regulation Of Neuron Projection Development Endoplasmic Reticulum Tubular Network Organization Generation Of Precursor Metabolites And Energy Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Negative Regulation Of Hormone Biosynthetic Process Pons Development Regulation Of Neuron Differentiation Cerebellar Purkinje Cell Differentiation Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Neurogenesis Reflex Cell Morphogenesis Involved In Differentiation Behavioral Response To Pain Axonal Fasciculation Neuromuscular Synaptic Transmission Negative Regulation Of Axon Extension Brain Development Cardiac Epithelial To Mesenchymal Transition Regulation Of Hormone Biosynthetic Process Head Development Cerebellar Cortex Formation Neuron Projection Development Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Regulation Of Cell Development Calcium Ion Import Regulation Of Hormone Metabolic Process Cerebellar Purkinje Cell Layer Development Membrane Depolarization During Action Potential Cation Transmembrane Transport Neuron Recognition Neuron Development Central Nervous System Development	Oxidative Phosphorylation Respiratory Electron Transport Chain Electron Transport Chain ATP Metabolic Process Cellular Macromolecule Catabolic Process Cellular Respiration Regulation Of Branching Morphogenesis Of A Nerve Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Electron Transport, Cytochrome C To Oxygen Purine Nucleoside Metabolic Process Skeletal Muscle Atrophy Circadian Regulation Of Translation Striated Muscle Atrophy Ribonucleotide Metabolic Process Muscle Atrophy Endoplasmic Reticulum Tubular Network Organization Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Purine Nucleotide Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Ribose Phosphate Metabolic Process Skeletal Muscle Adaptation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Generation Of Precursor Metabolites And Energy Aromatic Compound Catabolic Process Catabolic Process Apoptotic DNA Fragmentation Axonal Fasciculation Negative Regulation Of Axon Extension Nucleotide Metabolic Process Cardiac Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Cellular Response To Dexamethasone Stimulus Nucleobase-containing Small Molecule Metabolic Process Response To Dexamethasone Neuron Recognition Response To Electrical Stimulus Cerebral Cortex Radial Glia Guided Migration Endoplasmic Reticulum Organization Regulation Of MRNA Stability Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Regulation Of RNA Stability Epithelial To Mesenchymal Transition
Tagcloud ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 usp27x
Tagcloud (Difference) ?		angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 jam2 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 usp27x
Tagcloud (Intersection) ?