MGMT and CSNK2A2

Number of citations of the paper that reports this interaction (PubMedID 10667577)
0

Data Source:
BioGRID (enzymatic study)

		MGMT	CSNK2A2
Description		O-6-methylguanine-DNA methyltransferase	casein kinase 2 alpha 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Protein Kinase CK2 Complex PcG Protein Complex
	Molecular Function	DNA Binding Catalytic Activity Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Methyltransferase Activity DNA-methyltransferase Activity Transferase Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Repair DNA Alkylation Repair DNA Damage Response Methylation Negative Regulation Of Apoptotic Process Positive Regulation Of Double-strand Break Repair	Double-strand Break Repair Apoptotic Process DNA Damage Response Spermatogenesis Wnt Signaling Pathway Cerebral Cortex Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Liver Regeneration Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		MGMT-mediated DNA damage reversal	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		Cysteine Zinc S-Methylcysteine S-Benzylcysteine Dinitrochlorobenzene Zinc acetate Zinc chloride Zinc sulfate, unspecified form	[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease in APOE e4- carriers ( 25778476) Anorexia nervosa ( 31308545) Chronotype ( 30696823) Drug experimentation measurement ( 30718321) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431 29313844) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Lead levels ( 26025379) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) MGMT methylation in smokers ( 26183928) Modic changes ( 30808802) Response to temozolomide ( 23047291) Tea consumption ( 31046077) Triglyceride levels in HIV infection ( 33109212) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)	Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)
Interacting Genes		10 interacting genes: BCL2L13 CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PCNA PRKACA PRKCA UBA1	104 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CEBPA CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		4255	1459
HPRD ID		01135	00279
Ensembl ID		ENSG00000170430	ENSG00000070770
Uniprot IDs		B4DEE8 P16455	P19784
PDB IDs		1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH 8RGG 8RGH 8RTY 8RU2	3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H 7AT9 7ATV 7XYH 8Q77 8Q9S 8QBU 8QCD 8QCG 8QF1
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity Rhythmic Process N-terminal Peptidyl-lysine Acetylation Cellular Response To Stress Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Prostate Epithelial Cord Elongation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Damage Response Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Damaged DNA Binding Response To Stress Cell Death Apoptotic Process Protein Kinase Activity Programmed Cell Death Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Prostate Gland Growth Nucleus Cellular Response To UV Nucleobase-containing Compound Metabolic Process Regulation Of Smoothened Signaling Pathway Macromolecule Metabolic Process Transferase Activity N-terminal Protein Amino Acid Acetylation Kinase Activity Response To Hormone Branching Involved In Prostate Gland Morphogenesis Peptidyl-lysine Acetylation Branch Elongation Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Heat Cellular Response To Light Stimulus Protein Localization To Chromosome Response To Estradiol Protein Serine Kinase Activity Axis Elongation Acetyltransferase Activity Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity	Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Enzyme Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Alcohol Regulation Of Signal Transduction Regulation Of Metabolic Process Macromolecule Metabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Stress Response To Alkaloid Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of RNA Metabolic Process
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