MGMT

Gene Name		O-6-methylguanine-DNA methyltransferase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane
	Molecular Function	DNA Binding Damaged DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Calcium Ion Binding Methyltransferase Activity DNA-methyltransferase Activity
	Biological Process	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Response To Toxic Substance Cellular Response To Oxidative Stress Response To Drug Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of DNA Repair Response To Folic Acid Negative Regulation Of Cell Death Mammary Gland Epithelial Cell Differentiation Cellular Response To Organic Cyclic Compound Cellular Response To Ionizing Radiation
Pathways		DNA Damage Reversal
Drugs		L-Cysteine S-Methylcysteine Benzylcysteine
Diseases
GWAS		Response to temozolomide ( 23047291) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-protein Interactions		8 interactors: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PRKACA PRKCA UBA1
Entrez ID		4255
HPRD ID		01135
Ensembl ID
Uniprot IDs		B4DEE8 P16455
PDB IDs		1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis N-terminal Peptidyl-lysine Acetylation Histone H3-T6 Phosphorylation Chromatin Modification Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Mitotic Cell Cycle Process Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Phospholipase Activity Rhythmic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Cycle Histone Modification Cell Surface Receptor Signaling Pathway Apoptotic Process Regulation Of Mitotic Cell Cycle N-terminal Protein Amino Acid Acetylation Negative Regulation Of Glucose Import Cellular Protein Modification Process Positive Regulation Of Macrophage Differentiation Programmed Cell Death Chromosome Organization Desmosome Organization Cell Cycle Process Cell Death Death Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemotaxis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Cellular Response To Stimulus
Tagcloud ?		bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency ercc2 excision innate lines methylguanine methyltransferase modifying nitrosourea nucleotide o6 poor r repair resistance rich rodent sensitivity uv xpd