MGMT

Name	O-6-methylguanine-DNA methyltransferase
Structure
Novel Interactors	1 novel interactors: FGFR2
Interactors	10 interactors: BCL2L13 CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PCNA PRKACA PRKCA UBA1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane
	Molecular Function	DNA Binding Catalytic Activity Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Methyltransferase Activity DNA-methyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	DNA Repair DNA Alkylation Repair DNA Damage Response Methylation Negative Regulation Of Apoptotic Process Positive Regulation Of Double-strand Break Repair
Pathways	MGMT-mediated DNA damage reversal
Drugs	Cysteine Zinc S-Methylcysteine S-Benzylcysteine Dinitrochlorobenzene Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS	Adult body size ( 32376654 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Anorexia nervosa ( 31308545 ) Chronotype ( 30696823 ) Drug experimentation measurement ( 30718321 ) Gut microbiota (functional units) ( 27694959 ) Hand grip strength ( 29691431 29313844 ) HDL cholesterol levels in HIV infection ( 33109212 ) Heel bone mineral density ( 30598549 ) Inflammatory skin disease ( 25574825 ) Intraocular pressure ( 29617998 ) Iris color (a* coordinate) ( 30895295 ) Iris color (b* coordinate) ( 30895295 ) Lead levels ( 26025379 ) Metabolite levels ( 23823483 ) Metabolite levels (X-11787) ( 23934736 ) MGMT methylation in smokers ( 26183928 ) Modic changes ( 30808802 ) Response to temozolomide ( 23047291 ) Tea consumption ( 31046077 ) Triglyceride levels in HIV infection ( 33109212 ) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594 )
Entrez ID	4255
HPRD ID	01135
Ensembl ID	ENSG00000170430
Uniprot IDs	B4DEE8 P16455
PDB IDs	1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH 8RGG 8RGH 8RTY 8RU2
GO Terms Enriched among Interactors ?	Histone H3K18 Acetyltransferase Activity Rhythmic Process N-terminal Peptidyl-lysine Acetylation Cellular Response To Stress Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Prostate Epithelial Cord Elongation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Damage Response Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Damaged DNA Binding Response To Stress Cell Death Apoptotic Process Protein Kinase Activity Programmed Cell Death Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Prostate Gland Growth Nucleus Cellular Response To UV Nucleobase-containing Compound Metabolic Process Regulation Of Smoothened Signaling Pathway Macromolecule Metabolic Process Transferase Activity N-terminal Protein Amino Acid Acetylation Kinase Activity Response To Hormone Branching Involved In Prostate Gland Morphogenesis Peptidyl-lysine Acetylation Branch Elongation Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Heat Cellular Response To Light Stimulus Protein Localization To Chromosome Response To Estradiol Protein Serine Kinase Activity Axis Elongation Acetyltransferase Activity Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity