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MGMT
Description
O-6-methylguanine-DNA methyltransferase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Molecular Function
DNA Binding
Catalytic Activity
Methylated-DNA-[protein]-cysteine S-methyltransferase Activity
Methyltransferase Activity
DNA-methyltransferase Activity
Transferase Activity
Metal Ion Binding
Biological Process
DNA Repair
DNA Alkylation Repair
DNA Damage Response
Methylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Double-strand Break Repair
Pathways
MGMT-mediated DNA damage reversal
Drugs
Cysteine
Zinc
S-Methylcysteine
S-Benzylcysteine
Dinitrochlorobenzene
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Adult body size (
32376654
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Anorexia nervosa (
31308545
)
Chronotype (
30696823
)
Drug experimentation measurement (
30718321
)
Gut microbiota (functional units) (
27694959
)
Hand grip strength (
29691431
29313844
)
HDL cholesterol levels in HIV infection (
33109212
)
Heel bone mineral density (
30598549
)
Inflammatory skin disease (
25574825
)
Intraocular pressure (
29617998
)
Iris color (a* coordinate) (
30895295
)
Iris color (b* coordinate) (
30895295
)
Lead levels (
26025379
)
Metabolite levels (
23823483
)
Metabolite levels (X-11787) (
23934736
)
MGMT methylation in smokers (
26183928
)
Modic changes (
30808802
)
Response to temozolomide (
23047291
)
Tea consumption (
31046077
)
Triglyceride levels in HIV infection (
33109212
)
Waist-to-hip circumference ratio (ever vs never smoking interaction) (
23192594
)
Novel Interacting Genes
1 novel interacting genes:
FGFR2
Interacting Genes
10 interacting genes:
BCL2L13
CREBBP
CSNK2A1
CSNK2A2
EP300
ESR1
PCNA
PRKACA
PRKCA
UBA1
Entrez ID
4255
HPRD ID
01135
Ensembl ID
ENSG00000170430
Uniprot IDs
B4DEE8
P16455
PDB IDs
1EH6
1EH7
1EH8
1QNT
1T38
1T39
1YFH
8RGG
8RGH
8RTY
8RU2
Enriched GO Terms of Interacting Partners
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Histone H3K18 Acetyltransferase Activity
Rhythmic Process
N-terminal Peptidyl-lysine Acetylation
Cellular Response To Stress
Histone H3K27 Acetyltransferase Activity
Peptide Lactyltransferase (CoA-dependent) Activity
Protein Kinase CK2 Complex
Prostate Epithelial Cord Elongation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
DNA Damage Response
Transcription Coactivator Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Damaged DNA Binding
Response To Stress
Cell Death
Apoptotic Process
Protein Kinase Activity
Programmed Cell Death
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Prostate Gland Growth
Nucleus
Cellular Response To UV
Nucleobase-containing Compound Metabolic Process
Regulation Of Smoothened Signaling Pathway
Macromolecule Metabolic Process
Transferase Activity
N-terminal Protein Amino Acid Acetylation
Kinase Activity
Response To Hormone
Branching Involved In Prostate Gland Morphogenesis
Peptidyl-lysine Acetylation
Branch Elongation Of An Epithelium
Positive Regulation Of Establishment Of Protein Localization
Regulation Of Cellular Response To Heat
Cellular Response To Light Stimulus
Protein Localization To Chromosome
Response To Estradiol
Protein Serine Kinase Activity
Axis Elongation
Acetyltransferase Activity
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Autophagy
Negative Regulation Of Catabolic Process
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Tagcloud
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