MGMT and UBA1

Number of citations of the paper that reports this interaction (PMID 8573590)
36

Data Source:
HPRD (in vivo, in vitro)

		MGMT	UBA1
Gene Name		O-6-methylguanine-DNA methyltransferase	ubiquitin-like modifier activating enzyme 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Heterochromatin Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Damaged DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Calcium Ion Binding Methyltransferase Activity DNA-methyltransferase Activity	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Response To Toxic Substance Cellular Response To Oxidative Stress Response To Drug Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of DNA Repair Response To Folic Acid Negative Regulation Of Cell Death Mammary Gland Epithelial Cell Differentiation Cellular Response To Organic Cyclic Compound Cellular Response To Ionizing Radiation	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Modification-dependent Protein Catabolic Process
Pathways		DNA Damage Reversal	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		L-Cysteine S-Methylcysteine Benzylcysteine
Diseases
GWAS		Response to temozolomide ( 23047291) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		8 interactors: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PRKACA PRKCA UBA1	39 interactors: BUB3 CDC34 CDK1 CREB3L1 CREB3L2 ECHS1 GAN GRB2 HGS HSPH1 MGMT PIAS3 SEMA3F SMAD5 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2K UBE2L3 UBE2R2 UBE2S UBE2T UBE2W UBTD2
Entrez ID		4255	7317
HPRD ID		01135	02440
Ensembl ID			ENSG00000130985
Uniprot IDs		B4DEE8 P16455	P22314
PDB IDs		1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis N-terminal Peptidyl-lysine Acetylation Histone H3-T6 Phosphorylation Chromatin Modification Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Mitotic Cell Cycle Process Chromatin Organization Mitotic Cell Cycle Positive Regulation Of Phospholipase Activity Rhythmic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Cycle Histone Modification Cell Surface Receptor Signaling Pathway Apoptotic Process Regulation Of Mitotic Cell Cycle N-terminal Protein Amino Acid Acetylation Negative Regulation Of Glucose Import Cellular Protein Modification Process Positive Regulation Of Macrophage Differentiation Programmed Cell Death Chromosome Organization Desmosome Organization Cell Cycle Process Cell Death Death Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemotaxis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Cellular Response To Stimulus	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteolysis Catabolic Process Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Protein Monoubiquitination Cellular Response To Stress Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Response To Organic Substance Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 3 Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Spindle Assembly Checkpoint
Tagcloud ?		bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency ercc2 excision innate lines methylguanine methyltransferase modifying nitrosourea nucleotide o6 poor r repair resistance rich rodent sensitivity uv xpd	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Difference) ?		bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency ercc2 excision innate lines methylguanine methyltransferase modifying nitrosourea nucleotide o6 poor r repair resistance rich rodent sensitivity uv xpd	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Intersection) ?