TYROBP and KLRK1

Number of citations of the paper that reports this interaction (PMID 12426564)
74

Data Source:
HPRD (in vivo)

		TYROBP	KLRK1
Gene Name		TYRO protein tyrosine kinase binding protein	killer cell lectin-like receptor subfamily K, member 1
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Protein Binding Identical Protein Binding	Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Axon Guidance Intracellular Signal Transduction Innate Immune Response Regulation Of Immune Response Regulation Of Osteoclast Development	Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Signal regulatory protein (SIRP) family interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	7 interactors: HCST MICB RAE1 RAET1E RAET1G TYROBP ULBP3
Entrez ID		7305	22914
HPRD ID		04996	17240
Ensembl ID		ENSG00000011600	ENSG00000213809
Uniprot IDs		O43914	P26718
PDB IDs		2L34 2L35	1HYR 1KCG 1MPU
Enriched GO Terms of Interacting Partners?		Defense Response Innate Immune Response Immune Response Response To Stress Immune System Process Cellular Defense Response Beta Selection Positive Regulation Of Calcium-mediated Signaling Response To Stimulus Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Activation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Leukocyte Migration T Cell Selection Positive Regulation Of Alpha-beta T Cell Differentiation Hemopoiesis Positive Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Signal Transduction Locomotion Neutrophil Chemotaxis Neutrophil Migration Cell Activation Immune System Development Response To Other Organism Granulocyte Chemotaxis Regulation Of T Cell Activation Positive Regulation Of Cell Activation Natural Killer Cell Activation Alpha-beta T Cell Differentiation Response To Biotic Stimulus Positive Regulation Of CD40 Signaling Pathway Cytokine Secretion Involved In Immune Response Detection Of Lipoteichoic Acid Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Signaling Alpha-beta T Cell Activation Leukocyte Differentiation Cell Communication Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation	Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Leukocyte Mediated Immunity Antigen Processing And Presentation Innate Immune Response Regulation Of Immune Response T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Immune System Process Defense Response Antigen Processing And Presentation Of Peptide Antigen T Cell Mediated Immunity Immune System Process Leukocyte Activation Viral Process Cell Activation Response To Stress Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Osteoclast Development Gamma-delta T Cell Activation Adaptive Immune Response Neutrophil Activation Involved In Immune Response Negative Regulation Of Defense Response To Virus By Host Macrophage Activation Involved In Immune Response Lymphocyte Activation Neutrophil Activation Cytolysis Negative Regulation Of Defense Response To Virus Response To Stimulus Macrophage Activation Regulation Of Defense Response To Virus By Host Mitotic Nuclear Envelope Disassembly
Tagcloud ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	15rbeta aa alopecia areata autoreactive cd8 cytotoxic dermal effectors eliminated follicle gammac gwas hair ifn indicative infiltration jak jak1 janus nkg2d rational regrowth ruxolitinib signature signatures systemically therapeutically topical
Tagcloud (Difference) ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	15rbeta aa alopecia areata autoreactive cd8 cytotoxic dermal effectors eliminated follicle gammac gwas hair ifn indicative infiltration jak jak1 janus nkg2d rational regrowth ruxolitinib signature signatures systemically therapeutically topical
Tagcloud (Intersection) ?