TYROBP and KIR3DS1

Number of citations of the paper that reports this interaction (PMID 17202323)
45

Data Source:
HPRD (in vivo)

		TYROBP	KIR3DS1
Gene Name		TYRO protein tyrosine kinase binding protein	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Protein Binding Identical Protein Binding	MHC Class I Receptor Activity
	Biological Process	Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Axon Guidance Intracellular Signal Transduction Innate Immune Response Regulation Of Immune Response Regulation Of Osteoclast Development	Immune Response Signal Transduction Natural Killer Cell Activation Innate Immune Response
Pathways		DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Signal regulatory protein (SIRP) family interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	DAP12 interactions Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	2 interactors: HLA-B TYROBP
Entrez ID		7305	3813
HPRD ID		04996	10034
Ensembl ID		ENSG00000011600
Uniprot IDs		O43914	O43469 Q14943 Q4KN23 Q99565
PDB IDs		2L34 2L35
Enriched GO Terms of Interacting Partners?		Defense Response Innate Immune Response Immune Response Response To Stress Immune System Process Cellular Defense Response Beta Selection Positive Regulation Of Calcium-mediated Signaling Response To Stimulus Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Activation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Leukocyte Migration T Cell Selection Positive Regulation Of Alpha-beta T Cell Differentiation Hemopoiesis Positive Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Signal Transduction Locomotion Neutrophil Chemotaxis Neutrophil Migration Cell Activation Immune System Development Response To Other Organism Granulocyte Chemotaxis Regulation Of T Cell Activation Positive Regulation Of Cell Activation Natural Killer Cell Activation Alpha-beta T Cell Differentiation Response To Biotic Stimulus Positive Regulation Of CD40 Signaling Pathway Cytokine Secretion Involved In Immune Response Detection Of Lipoteichoic Acid Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Signaling Alpha-beta T Cell Activation Leukocyte Differentiation Cell Communication Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation	Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Osteoclast Development Regulation Of Dendritic Cell Differentiation Neutrophil Activation Involved In Immune Response Regulation Of T Cell Anergy Macrophage Activation Involved In Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Innate Immune Response Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Immune Response Detection Of Bacterium Neutrophil Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Detection Of Biotic Stimulus Macrophage Activation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Immune System Process Negative Regulation Of Innate Immune Response Defense Response Cellular Defense Response Regulation Of Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interleukin-12 Production Regulation Of Osteoclast Differentiation Response To External Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune System Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response Integrin-mediated Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Negative Regulation Of Immune Response Response To Interferon-gamma Leukocyte Activation Involved In Immune Response
Tagcloud ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	asian caucasians clustered han haplotype implied joining killer kir2dl2 kir2dl3 kir2dl5 kirs multidimensional neighbour outnumbered plot province southern ssp tree yunnan
Tagcloud (Difference) ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	asian caucasians clustered han haplotype implied joining killer kir2dl2 kir2dl3 kir2dl5 kirs multidimensional neighbour outnumbered plot province southern ssp tree yunnan
Tagcloud (Intersection) ?