TYROBP and TREM2

Number of citations of the paper that reports this interaction (PMID 12080485)
59

Data Source:
HPRD (in vivo)

		TYROBP	TREM2
Gene Name		TYRO protein tyrosine kinase binding protein	triggering receptor expressed on myeloid cells 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Protein Binding Identical Protein Binding	Lipopolysaccharide Binding Receptor Activity Peptidoglycan Binding Lipoteichoic Acid Binding Scaffold Protein Binding
	Biological Process	Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Axon Guidance Intracellular Signal Transduction Innate Immune Response Regulation Of Immune Response Regulation Of Osteoclast Development	Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Humoral Immune Response Axon Guidance Detection Of Lipopolysaccharide Detection Of Peptidoglycan Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Dendritic Cell Differentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of CD40 Signaling Pathway
Pathways		DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Signal regulatory protein (SIRP) family interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Innate Immune System
Drugs
Diseases
GWAS			C-reactive protein ( 22939635)
Protein-Protein Interactions		13 interactors: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	1 interactors: TYROBP
Entrez ID		7305	54209
HPRD ID		04996	05473
Ensembl ID		ENSG00000011600	ENSG00000095970
Uniprot IDs		O43914	Q5TCX1 Q9NZC2
PDB IDs		2L34 2L35
Enriched GO Terms of Interacting Partners?		Defense Response Innate Immune Response Immune Response Response To Stress Immune System Process Cellular Defense Response Beta Selection Positive Regulation Of Calcium-mediated Signaling Response To Stimulus Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Activation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Leukocyte Migration T Cell Selection Positive Regulation Of Alpha-beta T Cell Differentiation Hemopoiesis Positive Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Signal Transduction Locomotion Neutrophil Chemotaxis Neutrophil Migration Cell Activation Immune System Development Response To Other Organism Granulocyte Chemotaxis Regulation Of T Cell Activation Positive Regulation Of Cell Activation Natural Killer Cell Activation Alpha-beta T Cell Differentiation Response To Biotic Stimulus Positive Regulation Of CD40 Signaling Pathway Cytokine Secretion Involved In Immune Response Detection Of Lipoteichoic Acid Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Signaling Alpha-beta T Cell Activation Leukocyte Differentiation Cell Communication Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation	Regulation Of Osteoclast Development Neutrophil Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Macrophage Activation Cellular Defense Response Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Integrin-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation
Tagcloud ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	apoe4 apparatus arginine cysts detailed differs glycosylated glycosylation golgi gwas hakola histidine impaired modulatory mutated nasu nhd oligosaccharides phagocytosis polymorphism precise q33x r47h secretase snp t66m trafficking triggering y38c
Tagcloud (Difference) ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate	apoe4 apparatus arginine cysts detailed differs glycosylated glycosylation golgi gwas hakola histidine impaired modulatory mutated nasu nhd oligosaccharides phagocytosis polymorphism precise q33x r47h secretase snp t66m trafficking y38c
Tagcloud (Intersection) ?		trem2 triggering