KLRK1 and MICB

Number of citations of the paper that reports this interaction (PMID 12902493)
10

Data Source:
HPRD (in vitro)

		KLRK1	MICB
Gene Name		killer cell lectin-like receptor subfamily K, member 1	MHC class I polypeptide-related sequence B
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Receptor Activity Protein Binding Carbohydrate Binding	Antigen Binding Beta-2-microglobulin Binding Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	T Cell Mediated Cytotoxicity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Oxidative Stress Response To Heat Viral Process Cytolysis Antigen Processing And Presentation Response To Retinoic Acid Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Activation Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response
Pathways		DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	AIDS progression ( 19115949) Behcet's disease ( 23001997) Crohn's disease ( 23128233) Dengue shock syndrome ( 22001756) Hodgkin's lymphoma ( 22286212) Metabolic syndrome ( 22399527) Pulmonary function ( 21946350)
Protein-Protein Interactions		7 interactors: HCST MICB RAE1 RAET1E RAET1G TYROBP ULBP3	2 interactors: KLRC4 KLRK1
Entrez ID		22914	4277
HPRD ID		17240	03894
Ensembl ID		ENSG00000213809	ENSG00000204516
Uniprot IDs		P26718	A2AC57 F5H7Q8 Q29980 Q861E6
PDB IDs		1HYR 1KCG 1MPU	1JE6 2WY3
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Leukocyte Mediated Immunity Antigen Processing And Presentation Innate Immune Response Regulation Of Immune Response T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Immune System Process Defense Response Antigen Processing And Presentation Of Peptide Antigen T Cell Mediated Immunity Immune System Process Leukocyte Activation Viral Process Cell Activation Response To Stress Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Osteoclast Development Gamma-delta T Cell Activation Adaptive Immune Response Neutrophil Activation Involved In Immune Response Negative Regulation Of Defense Response To Virus By Host Macrophage Activation Involved In Immune Response Lymphocyte Activation Neutrophil Activation Cytolysis Negative Regulation Of Defense Response To Virus Response To Stimulus Macrophage Activation Regulation Of Defense Response To Virus By Host Mitotic Nuclear Envelope Disassembly	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Defense Response Cellular Defense Response Natural Killer Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Stress Regulation Of T Cell Activation Positive Regulation Of Cell Activation
Tagcloud ?		15rbeta aa alopecia areata autoreactive cd8 cytotoxic dermal effectors eliminated follicle gammac gwas hair ifn indicative infiltration jak jak1 janus nkg2d rational regrowth ruxolitinib signature signatures systemically therapeutically topical	aberrantly allogeneic autologous axis bcsc bcscs cytotoxicity downregulation elusive escape failed infiltrating killer killing limit metastasis mica mir20a nk nkg2d oncogenic promoted restored resultant rich sensitized stimulatory thereby trans
Tagcloud (Difference) ?		15rbeta aa alopecia areata autoreactive cd8 cytotoxic dermal effectors eliminated follicle gammac gwas hair ifn indicative infiltration jak jak1 janus rational regrowth ruxolitinib signature signatures systemically therapeutically topical	aberrantly allogeneic autologous axis bcsc bcscs cytotoxicity downregulation elusive escape failed infiltrating killer killing limit metastasis mica mir20a nk oncogenic promoted restored resultant rich sensitized stimulatory thereby trans
Tagcloud (Intersection) ?		nkg2d