KLRK1 and RAE1

Number of citations of the paper that reports this interaction (PubMedID 11520456)
0

Data Source:
BioGRID (pull down)

		KLRK1	RAE1
Description		killer cell lectin like receptor K1	ribonucleic acid export 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole
	Molecular Function	Protein Binding Carbohydrate Binding MHC Class Ib Receptor Activity Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Nitric Oxide Biosynthetic Process Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Positive Regulation Of Type II Interferon Production Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Positive Regulation Of Multicellular Organismal Process Cellular Response To Lipopolysaccharide Defense Response To Other Organism Negative Regulation Of Natural Killer Cell Chemotaxis	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)
Interacting Genes		8 interacting genes: HCST MICB PDE4C RAE1 RAET1E RAET1G TYROBP ULBP3	14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1
Entrez ID		22914	8480
HPRD ID		17240	11939
Ensembl ID		ENSG00000213809	ENSG00000101146
Uniprot IDs		P26718	P78406
PDB IDs		1HYR 1KCG 1MPU 4PDC 4S0U 8TM0 8TM2 9DH2	3MMY 4OWR 7F60 7F90 7VPG 7VPH
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Lectin-like Receptor Binding Natural Killer Cell Mediated Immunity Lymphocyte Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Cell Killing Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Immune Effector Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Regulation Of T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Immune Effector Process Innate Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune Response Defense Response To Symbiont Defense Response To Other Organism Antigen Processing And Presentation External Side Of Plasma Membrane Regulation Of T Cell Mediated Immunity Regulation Of Immune System Process Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Immune System Process Response To Other Organism Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Response To External Biotic Stimulus Positive Regulation Of Natural Killer Cell Mediated Immunity Defense Response Extracellular Space Positive Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Natural Killer Cell Mediated Immunity Response To Stress Regulation Of Innate Immune Response Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway	MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus
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