KLRK1 and HCST

Number of citations of the paper that reports this interaction (PMID 10426994)
135

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		KLRK1	HCST
Gene Name		killer cell lectin-like receptor subfamily K, member 1	hematopoietic cell signal transducer
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Receptor Activity Protein Binding Carbohydrate Binding	Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Immune Response
Pathways		DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: HCST MICB RAE1 RAET1E RAET1G TYROBP ULBP3	3 interactors: KLRK1 PIK3R1 SPOP
Entrez ID		22914	10870
HPRD ID		17240	04971
Ensembl ID		ENSG00000213809	ENSG00000126264
Uniprot IDs		P26718	Q9UBK5
PDB IDs		1HYR 1KCG 1MPU
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Leukocyte Mediated Immunity Antigen Processing And Presentation Innate Immune Response Regulation Of Immune Response T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Immune System Process Defense Response Antigen Processing And Presentation Of Peptide Antigen T Cell Mediated Immunity Immune System Process Leukocyte Activation Viral Process Cell Activation Response To Stress Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Osteoclast Development Gamma-delta T Cell Activation Adaptive Immune Response Neutrophil Activation Involved In Immune Response Negative Regulation Of Defense Response To Virus By Host Macrophage Activation Involved In Immune Response Lymphocyte Activation Neutrophil Activation Cytolysis Negative Regulation Of Defense Response To Virus Response To Stimulus Macrophage Activation Regulation Of Defense Response To Virus By Host Mitotic Nuclear Envelope Disassembly	T Cell Costimulation NFAT Protein Import Into Nucleus Glucose Homeostasis Positive Regulation Of T Cell Activation Transcription Factor Import Into Nucleus Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Regulation Of Cell Activation Leukocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Activation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Phosphatidylinositol 3-kinase Signaling Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Natural Killer Cell Mediated Immunity Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Growth Hormone Stimulus Innate Immune Response Negative Regulation Of Osteoclast Differentiation Chemical Homeostasis Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of RNA Splicing Negative Regulation Of Cell-matrix Adhesion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Transcription Factor Import Into Nucleus Response To Growth Hormone Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Glucose Import Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Glucose Transport Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		15rbeta aa alopecia areata autoreactive cd8 cytotoxic dermal effectors eliminated follicle gammac gwas hair ifn indicative infiltration jak jak1 janus nkg2d rational regrowth ruxolitinib signature signatures systemically therapeutically topical	1p36 bac bears border centromeric consists cort cortistatin d1s244 defines exonic exons ganglioneuromas intron kb mapping neuroblastoma neuroblastomas overlap p36 polymorphic preprocortistatin processed resemblance smallest somatostatin sst sstr
Tagcloud (Difference) ?		15rbeta aa alopecia areata autoreactive cd8 cytotoxic dermal effectors eliminated follicle gammac gwas hair ifn indicative infiltration jak jak1 janus nkg2d rational regrowth ruxolitinib signature signatures systemically therapeutically topical	1p36 bac bears border centromeric consists cort cortistatin d1s244 defines exonic exons ganglioneuromas intron kb mapping neuroblastoma neuroblastomas overlap p36 polymorphic preprocortistatin processed resemblance smallest somatostatin sst sstr
Tagcloud (Intersection) ?