TYROBP and SIRPB1

Number of citations of the paper that reports this interaction (PubMedID 10940905)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TYROBP	SIRPB1
Description		transmembrane immune signaling adaptor TYROBP	signal regulatory protein beta 1
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Immune Effector Process Myeloid Leukocyte Activation Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immune System Process Positive Regulation Of Immune System Process Defense Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Regulation Of Biological Quality Semaphorin-plexin Signaling Pathway Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Cell Surface Regulation Of Osteoclast Development Positive Regulation Of Osteoclast Development	Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	DAP12 interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Blood protein levels ( 30072576) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70	7 interacting genes: APOC1 BPIFA1 DAB1 MEOX2 RBFOX1 RBPMS TYROBP
Entrez ID		7305	10326
HPRD ID		04996	04866
Ensembl ID		ENSG00000011600	ENSG00000101307
Uniprot IDs		O43914 X6RGC9	H9KV29 O00241 Q5TFQ8
PDB IDs		2L34 2L35 4WO1 4WOL 7Q5W	2D9C 2JJU 2JJV
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Transmembrane Signaling Receptor Activity Regulation Of Immune Response Immune System Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Membrane Regulation Of Innate Immune Response Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Beta Selection Positive Regulation Of Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Cellular Defense Response Regulation Of Cell Activation Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Response Carbohydrate Binding Innate Immune Response-activating Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Calcium-mediated Signaling Regulation Of Natural Killer Cell Mediated Immunity Plasma Membrane Activation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Innate Immune Response Positive Regulation Of Cell Killing Immune Response Scaffold Protein Binding Positive Regulation Of Defense Response Lymphocyte Activation Regulation Of Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Defense Response Regulation Of Calcium-mediated Signaling Signaling Receptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phagocytosis Adaptive Immune Response	Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Phosphatidylcholine Catabolic Process Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Radial Glia-guided Pyramidal Neuron Migration Somite Specification Microglial Cell Activation Involved In Immune Response Molecular Adaptor Activity Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of RNA Splicing Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Ventral Spinal Cord Development T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Nuclear Stress Granule Phospholipase Inhibitor Activity Regulation Of Osteoclast Development Regulation Of Phosphatidylcholine Metabolic Process Very-low-density Lipoprotein Particle Assembly Cell Migration In Hindbrain Reelin-mediated Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Pre-mRNA Intronic Binding MRNA Binding Chylomicron Phospholipid Efflux
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