TYROBP and SIRPB1

Number of citations of the paper that reports this interaction (PMID 10604985)
25

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TYROBP	SIRPB1
Gene Name		TYRO protein tyrosine kinase binding protein	signal-regulatory protein beta 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Axon Guidance Intracellular Signal Transduction Innate Immune Response Regulation Of Immune Response Regulation Of Osteoclast Development	Signal Transduction Cell Surface Receptor Signaling Pathway Innate Immune Response
Pathways		DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Signal regulatory protein (SIRP) family interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	DAP12 interactions Signal regulatory protein (SIRP) family interactions Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	4 interactors: DAB1 MEOX2 RBPMS TYROBP
Entrez ID		7305	10326
HPRD ID		04996	04866
Ensembl ID		ENSG00000011600	ENSG00000101307
Uniprot IDs		O43914	H9KV29 O00241 Q5TFQ8
PDB IDs		2L34 2L35	2D9C 2JJU 2JJV
Enriched GO Terms of Interacting Partners?		Defense Response Innate Immune Response Immune Response Response To Stress Immune System Process Cellular Defense Response Beta Selection Positive Regulation Of Calcium-mediated Signaling Response To Stimulus Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Activation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Leukocyte Migration T Cell Selection Positive Regulation Of Alpha-beta T Cell Differentiation Hemopoiesis Positive Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Signal Transduction Locomotion Neutrophil Chemotaxis Neutrophil Migration Cell Activation Immune System Development Response To Other Organism Granulocyte Chemotaxis Regulation Of T Cell Activation Positive Regulation Of Cell Activation Natural Killer Cell Activation Alpha-beta T Cell Differentiation Response To Biotic Stimulus Positive Regulation Of CD40 Signaling Pathway Cytokine Secretion Involved In Immune Response Detection Of Lipoteichoic Acid Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Signaling Alpha-beta T Cell Activation Leukocyte Differentiation Cell Communication Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation	Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Cerebellum Structural Organization Lateral Motor Column Neuron Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Somite Specification Regulation Of Osteoclast Development Neutrophil Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Positive Regulation Of SMAD Protein Import Into Nucleus Golgi Localization Negative Regulation Of Astrocyte Differentiation Regulation Of SMAD Protein Import Into Nucleus Segment Specification Midgut Development Anatomical Structure Arrangement Neutrophil Activation Negative Regulation Of JAK-STAT Cascade Cell Migration In Hindbrain Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Astrocyte Differentiation Macrophage Activation Positive Regulation Of Protein Phosphorylation
Tagcloud ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	approved candidate cliques consensuspathdb dap12 databases designated eitology etiology fda hepatocellular implicates implicating incidences kegg lck mediator modules network pid ppi rara reactome schizophrenia schizophrenic searching shcn syk trem
Tagcloud (Difference) ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	approved candidate cliques consensuspathdb dap12 databases designated eitology etiology fda hepatocellular implicates implicating incidences kegg lck mediator modules network pid ppi rara reactome schizophrenia schizophrenic searching shcn syk trem
Tagcloud (Intersection) ?